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DOI | 10.1038/s41467-017-02709-4 |
HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs | |
Li, Jingting1; Chen, Yifang1; Xu, Xiaojun2; Jones, Jackson1; Tiwari, Manisha1; Ling, Ji1; Wang, Ying1; Harismendy, Olivier2,3; Sen, George L.1 | |
2019-09-13 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Maintenance of high-turnover tissues such as the epidermis requires a balance between stem cell proliferation and differentiation. The molecular mechanisms governing this process are an area of investigation. Here we show that HNRNPK, a multifunctional protein, is necessary to prevent premature differentiation and sustains the proliferative capacity of epidermal stem and progenitor cells. To prevent premature differentiation of progenitor cells, HNRNPK is necessary for DDX6 to bind a subset of mRNAs that code for transcription factors that promote differentiation. Upon binding, these mRNAs such as GRHL3, KLF4, and ZNF750 are degraded through the mRNA degradation pathway, which prevents premature differentiation. To sustain the proliferative capacity of the epidermis, HNRNPK is necessary for RNA Polymerase II binding to proliferation/self-renewal genes such as MYC, CYR61, FGFBP1, EGFR, and cyclins to promote their expression. Our study establishes a prominent role for HNRNPK in maintaining adult tissue self-renewal through both transcriptional and post-transcriptional mechanisms. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000485685900037 |
WOS关键词 | NUCLEAR RIBONUCLEOPROTEIN-K ; SELF-RENEWAL ; STEM-CELLS ; EXPRESSION ; BINDING ; TISSUE ; ALPHA ; PHOSPHORYLATION ; TERMINATION ; REVEALS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203644 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Calif San Diego, UCSD Stem Cell Program, Dept Cellular & Mol Med, Dept Dermatol, La Jolla, CA 92093 USA; 2.Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA; 3.Univ Calif San Diego, Dept Biomed Informat, La Jolla, CA 92093 USA |
推荐引用方式 GB/T 7714 | Li, Jingting,Chen, Yifang,Xu, Xiaojun,et al. HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Li, Jingting.,Chen, Yifang.,Xu, Xiaojun.,Jones, Jackson.,Tiwari, Manisha.,...&Sen, George L..(2019).HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs.NATURE COMMUNICATIONS,10. |
MLA | Li, Jingting,et al."HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs".NATURE COMMUNICATIONS 10(2019). |
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