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DOI | 10.1038/s41467-018-02922-9 |
Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa | |
Francis, Vanessa I.1; Waters, Elaine M.2; Finton-James, Sutharsan E.1; Gori, Andrea1; Kadioglu, Aras2; Brown, Alan R.1; Porter, Steven L.1 | |
2018-06-07 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | England |
英文摘要 | Bacteria and many non-metazoan Eukaryotes respond to stresses and threats using two-component systems (TCSs) comprising sensor kinases (SKs) and response regulators (RRs). Multikinase networks, where multiple SKs work together, detect and integrate different signals to control important lifestyle decisions such as sporulation and virulence. Here, we study interactions between two SKs from Pseudomonas aeruginosa, GacS and RetS, which control the switch between acute and chronic virulence. We demonstrate three mechanisms by which RetS attenuates GacS signalling: RetS takes phosphoryl groups from GacS-P; RetS has transmitter phosphatase activity against the receiver domain of GacS-P; and RetS inhibits GacS autophosphorylation. These mechanisms play important roles in vivo and during infection, and exemplify an unprecedented degree of signal processing by SKs that may be exploited in other multikinase networks. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000434379800016 |
WOS关键词 | 2-COMPONENT SIGNAL-TRANSDUCTION ; CONTROLS BIOFILM FORMATION ; MYXOCOCCUS-XANTHUS ; CROSS-TALK ; RHODOBACTER-SPHAEROIDES ; PERSISTENT INFECTIONS ; III SECRETION ; LIFE-STYLE ; IN-VIVO ; SYSTEM |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203652 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Exeter, Coll Life & Environm Sci, Biosci, Geoffrey Pope Bldg, Exeter EX4 4QD, Devon, England; 2.Univ Liverpool, Inst Infect & Global Hlth, Dept Clin Infect Microbiol & Immunol, Liverpool L69 7BE, Merseyside, England |
推荐引用方式 GB/T 7714 | Francis, Vanessa I.,Waters, Elaine M.,Finton-James, Sutharsan E.,et al. Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Francis, Vanessa I..,Waters, Elaine M..,Finton-James, Sutharsan E..,Gori, Andrea.,Kadioglu, Aras.,...&Porter, Steven L..(2018).Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa.NATURE COMMUNICATIONS,9. |
MLA | Francis, Vanessa I.,et al."Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa".NATURE COMMUNICATIONS 9(2018). |
条目包含的文件 | 条目无相关文件。 |
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