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DOI | 10.1038/s41467-018-02954-1 |
Programmed cell removal by calreticulin in tissue homeostasis and cancer | |
Feng, Mingye1,2; Marjon, Kristopher D.1,3,4; Zhu, Fangfang1,3,4; Weissman-Tsukamoto, Rachel1,3,4; Levett, Aaron1,3,4; Sullivan, Katie1,3,4; Kao, Kevin S.1,3,4; Markovic, Maxim1,3,4; Bump, Paul A.1,3,4; Jackson, Hannah M.1,3,4; Choi, Timothy S.1,3,4; Chen, Jing5,6,7; Banuelos, Allison M.1,3,4; Liu, Jie1,3,4; Gip, Phung1,3,4; Cheng, Lei5,6,7; Wang, Denong8; Weissman, Irving L.1,3,4,9 | |
2018-08-10 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Peoples R China |
英文摘要 | Macrophage-mediated programmed cell removal (PrCR) is a process essential for the clearance of unwanted (damaged, dysfunctional, aged, or harmful) cells. The detection and recognition of appropriate target cells by macrophages is a critical step for successful PrCR, but its molecular mechanisms have not been delineated. Here using the models of tissue turnover, cancer immunosurveillance, and hematopoietic stem cells, we show that unwanted cells such as aging neutrophils and living cancer cells are susceptible to "labeling" by secreted calreticulin (CRT) from macrophages, enabling their clearance through PrCR. Importantly, we identified asialoglycans on the target cells to which CRT binds to regulate PrCR, and the availability of such CRT-binding sites on cancer cells correlated with the prognosis of patients in various malignancies. Our study reveals a general mechanism of target cell recognition by macrophages, which is the key for the removal of unwanted cells by PrCR in physiological and pathophysiological processes. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000441306000001 |
WOS关键词 | GENE-EXPRESSION PROFILE ; HEMATOPOIETIC STEM-CELL ; ACUTE MYELOID-LEUKEMIA ; MHC CLASS-I ; SURFACE CALRETICULIN ; ACUTE-INFLAMMATION ; APOPTOTIC CELLS ; TYROSINE KINASE ; PHAGOCYTOSIS ; MACROPHAGES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203654 |
专题 | 资源环境科学 |
作者单位 | 1.Stanford Univ, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA; 2.Beckman Res Inst, Dept Immunooncol, City Hope Comprehens Canc Ctr, Duarte, CA 91010 USA; 3.Stanford Univ, Ludwig Ctr Canc Stem Cell Res & Med, Stanford, CA 94305 USA; 4.Stanford Univ, Stanford Canc Inst, Stanford, CA 94305 USA; 5.Sichuan Univ, State Key Lab Oral Dis, Chengdu 610041, Sichuan, Peoples R China; 6.Sichuan Univ, Natl Clin Res Ctr Oral Dis, Chengdu 610041, Sichuan, Peoples R China; 7.Sichuan Univ, West China Hosp Stomatol, Chengdu 610041, Sichuan, Peoples R China; 8.SRI Int, 333 Ravenswood Ave, Menlo Pk, CA 94025 USA; 9.Stanford Univ, Dept Pathol, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Feng, Mingye,Marjon, Kristopher D.,Zhu, Fangfang,et al. Programmed cell removal by calreticulin in tissue homeostasis and cancer[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Feng, Mingye.,Marjon, Kristopher D..,Zhu, Fangfang.,Weissman-Tsukamoto, Rachel.,Levett, Aaron.,...&Weissman, Irving L..(2018).Programmed cell removal by calreticulin in tissue homeostasis and cancer.NATURE COMMUNICATIONS,9. |
MLA | Feng, Mingye,et al."Programmed cell removal by calreticulin in tissue homeostasis and cancer".NATURE COMMUNICATIONS 9(2018). |
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