Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-018-02992-9 |
Enhanced diffusion by binding to the crosslinks of a polymer gel | |
Goodrich, Carl P.1,2; Brenner, Michael P.1,2; Ribbeck, Katharina3 | |
2018-10-19 | |
发表期刊 | NATURE COMMUNICATIONS
![]() |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Creating a selective gel that filters particles based on their interactions is a major goal of nanotechnology, with far-reaching implications from drug delivery to controlling assembly pathways. However, this is particularly difficult when the particles are larger than the gel's characteristic mesh size because such particles cannot passively pass through the gel. Thus, filtering requires the interacting particles to transiently reorganize the gel's internal structure. While significant advances, e.g., in DNA engineering, have enabled the design of nano-materials with programmable interactions, it is not clear what physical principles such a designer gel could exploit to achieve selective permeability. We present an equilibrium mechanism where crosslink binding dynamics are affected by interacting particles such that particle diffusion is enhanced. In addition to revealing specific design rules for manufacturing selective gels, our results have the potential to explain the origin of selective permeability in certain biological materials, including the nuclear pore complex. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000447697100006 |
WOS关键词 | NUCLEAR-PORE COMPLEX ; EXTRACELLULAR-MATRIX ; STRUCTURAL BASIS ; IMPORTIN-BETA ; COLLAGEN GELS ; DNA HYDROGEL ; FG REPEAT ; NUCLEOPORINS ; TRANSPORT ; RAN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203710 |
专题 | 资源环境科学 |
作者单位 | 1.Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA; 2.Harvard Univ, Kavli Inst Bionano Sci & Technol, Cambridge, MA 02138 USA; 3.MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA |
推荐引用方式 GB/T 7714 | Goodrich, Carl P.,Brenner, Michael P.,Ribbeck, Katharina. Enhanced diffusion by binding to the crosslinks of a polymer gel[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Goodrich, Carl P.,Brenner, Michael P.,&Ribbeck, Katharina.(2018).Enhanced diffusion by binding to the crosslinks of a polymer gel.NATURE COMMUNICATIONS,9. |
MLA | Goodrich, Carl P.,et al."Enhanced diffusion by binding to the crosslinks of a polymer gel".NATURE COMMUNICATIONS 9(2018). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论