Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-018-03629-7 |
Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry | |
Juan, Thomas; Geminard, Charles; Coutelis, Jean-Baptiste; Cerezo, Delphine; Poles, Sophie; Noselli, Stephane; Fuerthauer, Maximilian | |
2018-05-16 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | France |
英文摘要 | The establishment of left-right (LR) asymmetry is fundamental to animal development, but the identification of a unifying mechanism establishing laterality across different phyla has remained elusive. A cilia-driven, directional fluid flow is important for symmetry breaking in numerous vertebrates, including zebrafish. Alternatively, LR asymmetry can be established independently of cilia, notably through the intrinsic chirality of the acto-myosin cytoskeleton. Here, we show that Myosin1D (Myo1D), a previously identified regulator of Drosophila LR asymmetry, is essential for the formation and function of the zebrafish LR organizer (LRO), Kupffer's vesicle (KV). Myo1D controls the orientation of LRO cilia and interacts functionally with the planar cell polarity (PCP) pathway component VanGogh-like2 (Vangl2), to shape a productive LRO flow. Our findings identify Myo1D as an evolutionarily conserved regulator of animal LR asymmetry, and show that functional interactions between Myo1D and PCP are central to the establishment of animal LR asymmetry. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000432279600003 |
WOS关键词 | PLANAR CELL POLARITY ; BREAKS BILATERAL SYMMETRY ; KUPFFERS VESICLE ; UNCONVENTIONAL MYOSIN ; LEFT/RIGHT ASYMMETRY ; ENDODERM FORMATION ; SELF-ORGANIZATION ; ZEBRAFISH EMBRYO ; LATERALITY ORGAN ; PROTEIN VANGL2 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203726 |
专题 | 资源环境科学 |
作者单位 | Univ Cote dAzur, CNRS, Inserm, Inst Biol Valrose, F-06108 Nice, France |
推荐引用方式 GB/T 7714 | Juan, Thomas,Geminard, Charles,Coutelis, Jean-Baptiste,et al. Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Juan, Thomas.,Geminard, Charles.,Coutelis, Jean-Baptiste.,Cerezo, Delphine.,Poles, Sophie.,...&Fuerthauer, Maximilian.(2018).Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry.NATURE COMMUNICATIONS,9. |
MLA | Juan, Thomas,et al."Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry".NATURE COMMUNICATIONS 9(2018). |
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