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DOI | 10.1038/s41467-018-03756-1 |
Infralimbic cortex is required for learning alternatives to prelimbic promoted associations through reciprocal connectivity | |
Mukherjee, Arghya; Caroni, Pico | |
2018-07-13 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland |
英文摘要 | Prefrontal cortical areas mediate flexible adaptive control of behavior, but the specific contributions of individual areas and the circuit mechanisms through which they interact to modulate learning have remained poorly understood. Using viral tracing and pharmacogenetic techniques, we show that prelimbic (PreL) and infralimbic cortex (IL) exhibit reciprocal PreL <-> IL layer 5/6 connectivity. In set-shifting tasks and in fear/extinction learning, activity in PreL is required during new learning to apply previously learned associations, whereas activity in IL is required to learn associations alternative to previous ones. IL -> PreL connectivity is specifically required during IL-dependent learning, whereas reciprocal PreL <-> IL connectivity is required during a time window of 12-14 h after association learning, to set up the role of IL in subsequent learning. Our results define specific and opposing roles of PreL and IL to together flexibly support new learning, and provide circuit evidence that IL-mediated learning of alternative associations depends on direct reciprocal PreL <-> IL connectivity. |
领域 | 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000438495300001 |
WOS关键词 | MEDIAL PREFRONTAL CORTEX ; FRONTAL-CORTEX ; INTRINSIC EXCITABILITY ; BASOLATERAL AMYGDALA ; MEMORY CONSOLIDATION ; BEHAVIORAL-CONTROL ; HABITUAL BEHAVIOR ; NEURONAL CIRCUITS ; FEAR ; EXTINCTION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203764 |
专题 | 资源环境科学 |
作者单位 | Friedrich Miescher Inst, CH-4058 Basel, Switzerland |
推荐引用方式 GB/T 7714 | Mukherjee, Arghya,Caroni, Pico. Infralimbic cortex is required for learning alternatives to prelimbic promoted associations through reciprocal connectivity[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Mukherjee, Arghya,&Caroni, Pico.(2018).Infralimbic cortex is required for learning alternatives to prelimbic promoted associations through reciprocal connectivity.NATURE COMMUNICATIONS,9. |
MLA | Mukherjee, Arghya,et al."Infralimbic cortex is required for learning alternatives to prelimbic promoted associations through reciprocal connectivity".NATURE COMMUNICATIONS 9(2018). |
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