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DOI | 10.1038/s41467-018-04312-7 |
Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair | |
Niida, Hiroyuki1; Matsunuma, Ryoichi1,2; Horiguchi, Ryo3; Uchida, Chiharu3; Nakazawa, Yuka4; Motegi, Akira5; Nishimoto, Koji1; Sakai, Satoshi1; Ohhata, Tatsuya1; Kitagawa, Kyoko1; Moriwaki, Shinichi6; Nishitani, Hideo7; Ui, Ayako8,9,10; Ogi, Tomoo11; Kitagawa, Masatoshi1,12 | |
2017-07-18 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Japan |
英文摘要 | HBO1, a histone acetyl transferase, is a co-activator of DNA pre-replication complex formation. We recently reported that HBO1 is phosphorylated by ATM and/or ATR and binds to DDB2 after ultraviolet irradiation. Here, we show that phosphorylated HBO1 at cyclobutane pyrimidine dimer (CPD) sites mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites. Furthermore, HBO1 facilitates accumulation of SNF2H and ACF1, an ATP-dependent chromatin remodelling complex, to CPD sites. Depletion of HBO1 inhibited repair of CPDs and sensitized cells to ultraviolet irradiation. However, depletion of HBO1 in cells derived from xeroderma pigmentosum patient complementation groups, XPE, XPC and XPA, did not lead to additional sensitivity towards ultraviolet irradiation. Our findings suggest that HBO1 acts in concert with SNF2H-ACF1 to make the chromosome structure more accessible to canonical nucleotide excision repair factors. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000405727600001 |
WOS关键词 | GLOBAL GENOMIC REPAIR ; PIGMENTOSUM GROUP-E ; XERODERMA-PIGMENTOSUM ; DNA-DAMAGE ; UBIQUITIN LIGASE ; IN-VIVO ; COMPLEMENTATION GROUPS ; H3K14 ACETYLATION ; PROTEIN COMPLEX ; CHROMATIN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203810 |
专题 | 资源环境科学 |
作者单位 | 1.Hamamatsu Univ Sch Med, Dept Mol Biol, Higashi Ku, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan; 2.Hamamatsu Univ Sch Med, Dept Surg 1, Higashi Ku, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan; 3.Hamamatsu Univ Sch Med, Preeminent Med Photon Educ & Res Ctr, Adv Res Facil & Serv, Higashi Ku, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan; 4.Nagasaki Univ, Dept Genome Repair, Atom Bomb Dis Inst, 1-12-4 Sakamoto, Nagasaki 8528523, Japan; 5.Kyoto Univ, Dept Radiat Genet, Grad Sch Med, Kyoto 6068501, Japan; 6.Osaka Med Coll, Dept Dermatol, 2-7 Daigaku Machi, Takatsuki, Osaka 5698686, Japan; 7.Univ Hyogo, Grad Sch Life Sci, 3-2-1 Kouto, Kamigori, Hyogo 6781297, Japan; 8.St Marianna Univ, Sch Med, Dept Translat Oncol, Miyamae Ku, 2-16-1 Sugao, Kawasaki, Kanagawa 2168511, Japan; 9.St Marianna Univ, Sch Med, Inst Med Sci, Miyamae Ku, 2-16-1 Sugao, Kawasaki, Kanagawa 2168511, Japan; 10.Tokyo Univ Technol, Sch Biosci & Biotechnol, Dept Genome Regulat & Mol Pharmacogen, 1404-1 Katakuramachi, Hachioji, Tokyo 1920983, Japan; 11.Nagoya Univ, Res Inst Environm Med, Dept Genet, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648601, Japan; 12.Hamamatsu Univ Sch Med, Lab Anim Facil & Serv, Preeminent Med Photon Educ & Res Ctr, Higashi Ku, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan |
推荐引用方式 GB/T 7714 | Niida, Hiroyuki,Matsunuma, Ryoichi,Horiguchi, Ryo,et al. Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Niida, Hiroyuki.,Matsunuma, Ryoichi.,Horiguchi, Ryo.,Uchida, Chiharu.,Nakazawa, Yuka.,...&Kitagawa, Masatoshi.(2017).Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair.NATURE COMMUNICATIONS,8. |
MLA | Niida, Hiroyuki,et al."Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair".NATURE COMMUNICATIONS 8(2017). |
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