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DOI | 10.1038/s41467-018-05080-0 |
Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo | |
See, Kelvin1; Tan, Wilson L. W.1,2; Lim, Eng How1,2; Tiang, Zenia1,2; Lee, Li Ting1; Li, Peter Y. Q.2; Luu, Tuan D. A.2; Ackers-Johnson, Matthew2; Foo, Roger S.1,2 | |
2017-08-09 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Singapore |
英文摘要 | Cardiac regeneration may revolutionize treatment for heart failure but endogenous progenitor-derived cardiomyocytes in the adult mammalian heart are few and pre-existing adult cardiomyocytes divide only at very low rates. Although candidate genes that control cardiomyocyte cell cycle re-entry have been implicated, expression heterogeneity in the cardiomyocyte stress-response has never been explored. Here, we show by single nuclear RNA-sequencing of cardiomyocytes from both mouse and human failing, and non-failing adult hearts that sub-populations of cardiomyocytes upregulate cell cycle activators and inhibitors consequent to the stress-response in vivo. We characterize these subgroups by weighted gene co-expression network analysis and discover long intergenic non-coding RNAs ( lincRNA) as key nodal regulators. KD of nodal lincRNAs affects expression levels of genes related to dedifferentiation and cell cycle, within the same gene regulatory network. Our study reveals that sub-populations of adult cardiomyocytes may have a unique endogenous potential for cardiac regeneration in vivo. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000407198800014 |
WOS关键词 | CONGENITAL HEART-DISEASE ; RNA-SEQ ; ADULT HEART ; CARDIAC REGENERATION ; MOUSE HEART ; PROLIFERATION ; EXPRESSION ; RENEWAL ; ARREST ; REPAIR |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203870 |
专题 | 资源环境科学 |
作者单位 | 1.Genome Inst Singapore, 60 Biopolis St, Singapore 138672, Singapore; 2.Natl Univ Hlth Syst, Cardiovasc Res Inst, Ctr Translat Med, 14 Med Dr, Singapore 117599, Singapore |
推荐引用方式 GB/T 7714 | See, Kelvin,Tan, Wilson L. W.,Lim, Eng How,et al. Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo[J]. NATURE COMMUNICATIONS,2017,8. |
APA | See, Kelvin.,Tan, Wilson L. W..,Lim, Eng How.,Tiang, Zenia.,Lee, Li Ting.,...&Foo, Roger S..(2017).Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo.NATURE COMMUNICATIONS,8. |
MLA | See, Kelvin,et al."Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo".NATURE COMMUNICATIONS 8(2017). |
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