Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-018-05516-7 |
Diversity of meso-scale architecture in human and non-human connectomes | |
Betzel, Richard F.1; Medaglia, John D.2,3; Bassett, Danielle S.1,3,4 | |
2018-01-24 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Brain function is reflected in connectome community structure. The dominant view is that communities are assortative and segregated from one another, supporting specialized information processing. However, this view precludes the possibility of non-assortative communities whose complex inter-community interactions could engender a richer functional repertoire. We use weighted stochastic blockmodels to uncover the meso-scale architecture of Drosophila, mouse, rat, macaque, and human connectomes. We find that most communities are assortative, though others form core-periphery and disassortative structures, which better recapitulate observed patterns of functional connectivity and gene co-expression in human and mouse connectomes compared to standard community detection techniques. We define measures for quantifying the diversity of communities in which brain regions participate, showing that this measure is peaked in control and subcortical systems in humans, and that inter-individual differences are correlated with cognitive performance. Our report paints a more diverse portrait of connectome communities and demonstrates their cognitive relevance. |
领域 | 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000423155700004 |
WOS关键词 | FUNCTIONAL CONNECTIVITY ; DIRECTION-SELECTIVITY ; RICH-CLUB ; BRAIN ; ORGANIZATION ; NETWORKS ; TASK ; REVEALS ; HUBS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203913 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA; 2.Drexel Univ, Dept Psychol, Philadelphia, PA 19104 USA; 3.Univ Penn, Perelman Sch Med, Dept Neurol, Philadelphia, PA 19104 USA; 4.Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA |
推荐引用方式 GB/T 7714 | Betzel, Richard F.,Medaglia, John D.,Bassett, Danielle S.. Diversity of meso-scale architecture in human and non-human connectomes[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Betzel, Richard F.,Medaglia, John D.,&Bassett, Danielle S..(2018).Diversity of meso-scale architecture in human and non-human connectomes.NATURE COMMUNICATIONS,9. |
MLA | Betzel, Richard F.,et al."Diversity of meso-scale architecture in human and non-human connectomes".NATURE COMMUNICATIONS 9(2018). |
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