GSTDTAP  > 资源环境科学
DOI10.1038/s41467-018-05516-7
Diversity of meso-scale architecture in human and non-human connectomes
Betzel, Richard F.1; Medaglia, John D.2,3; Bassett, Danielle S.1,3,4
2018-01-24
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
出版年2018
卷号9
文章类型Article
语种英语
国家USA
英文摘要

Brain function is reflected in connectome community structure. The dominant view is that communities are assortative and segregated from one another, supporting specialized information processing. However, this view precludes the possibility of non-assortative communities whose complex inter-community interactions could engender a richer functional repertoire. We use weighted stochastic blockmodels to uncover the meso-scale architecture of Drosophila, mouse, rat, macaque, and human connectomes. We find that most communities are assortative, though others form core-periphery and disassortative structures, which better recapitulate observed patterns of functional connectivity and gene co-expression in human and mouse connectomes compared to standard community detection techniques. We define measures for quantifying the diversity of communities in which brain regions participate, showing that this measure is peaked in control and subcortical systems in humans, and that inter-individual differences are correlated with cognitive performance. Our report paints a more diverse portrait of connectome communities and demonstrates their cognitive relevance.


领域资源环境
收录类别SCI-E ; SSCI
WOS记录号WOS:000423155700004
WOS关键词FUNCTIONAL CONNECTIVITY ; DIRECTION-SELECTIVITY ; RICH-CLUB ; BRAIN ; ORGANIZATION ; NETWORKS ; TASK ; REVEALS ; HUBS
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/203913
专题资源环境科学
作者单位1.Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA;
2.Drexel Univ, Dept Psychol, Philadelphia, PA 19104 USA;
3.Univ Penn, Perelman Sch Med, Dept Neurol, Philadelphia, PA 19104 USA;
4.Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA
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Betzel, Richard F.,Medaglia, John D.,Bassett, Danielle S.. Diversity of meso-scale architecture in human and non-human connectomes[J]. NATURE COMMUNICATIONS,2018,9.
APA Betzel, Richard F.,Medaglia, John D.,&Bassett, Danielle S..(2018).Diversity of meso-scale architecture in human and non-human connectomes.NATURE COMMUNICATIONS,9.
MLA Betzel, Richard F.,et al."Diversity of meso-scale architecture in human and non-human connectomes".NATURE COMMUNICATIONS 9(2018).
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