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DOI | 10.1038/s41467-018-05415-x |
INO80 exchanges H2A.Z for H2A by translocating on DNA proximal to histone dimers | |
Brahma, Sandipan1,2,3; Udugama, Maheshi I.3,6; Kim, Jongseong4,5,7; Hada, Arjan1,2,3; Bhardwaj, Saurabh K.1,2,3,8,9; Hailu, Solomon G.1,2,3; Lee, Tae-Hee4,5; Bartholomew, Blaine1,2 | |
2017-06-12 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Australia; South Korea |
英文摘要 | ATP-dependent chromatin remodellers modulate nucleosome dynamics by mobilizing or disassembling nucleosomes, as well as altering nucleosome composition. These chromatin remodellers generally function by translocating along nucleosomal DNA at the H3-H4 interface of nucleosomes. Here we show that, unlike other remodellers, INO80 translocates along DNA at the H2A-H2B interface of nucleosomes and persistently displaces DNA from the surface of H2A-H2B. DNA translocation and DNA torsional strain created near the entry site of nucleosomes by INO80 promotes both the mobilization of nucleosomes and the selective exchange of H2A.Z-H2B dimers out of nucleosomes and replacement by H2A-H2B dimers without any additional histone chaperones. We find that INO80 translocates and mobilizes H2A. Z-containing nucleosomes more efficiently than those containing H2A, partially accounting for the preference of INO80 to replace H2A.Z with H2A. Our data suggest that INO80 has a mechanism for dimer exchange that is distinct from other chromatin remodellers including its paralogue SWR1. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000403064300001 |
WOS关键词 | CHROMATIN REMODELING COMPLEX ; NUCLEOSOME CORE PARTICLE ; STRAND BREAK REPAIR ; SWR-C ; SACCHAROMYCES-CEREVISIAE ; ANGSTROM RESOLUTION ; CATALYTIC SUBUNIT ; CRYSTAL-STRUCTURE ; VARIANT ; TRANSCRIPTION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203914 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Texas MD Anderson Canc Ctr, Dept Epigenet & Mol Carcinogenesis, Smithville, TX 78957 USA; 2.Univ Texas MD Anderson Canc Ctr, Ctr Canc Epigenet, Houston, TX 77030 USA; 3.Southern Illinois Univ, Sch Med, Grad Program Mol Biol Microbiol & Biochem, Carbondale, IL 62901 USA; 4.Penn State Univ, Dept Chem, University Pk, PA 16802 USA; 5.Penn State Univ, Huck Inst Life Sci, University Pk, PA 16802 USA; 6.Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic, Australia; 7.Yonsei Univ, Yonsei IBS Inst, Seoul 03722, South Korea; 8.Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA; 9.Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA |
推荐引用方式 GB/T 7714 | Brahma, Sandipan,Udugama, Maheshi I.,Kim, Jongseong,et al. INO80 exchanges H2A.Z for H2A by translocating on DNA proximal to histone dimers[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Brahma, Sandipan.,Udugama, Maheshi I..,Kim, Jongseong.,Hada, Arjan.,Bhardwaj, Saurabh K..,...&Bartholomew, Blaine.(2017).INO80 exchanges H2A.Z for H2A by translocating on DNA proximal to histone dimers.NATURE COMMUNICATIONS,8. |
MLA | Brahma, Sandipan,et al."INO80 exchanges H2A.Z for H2A by translocating on DNA proximal to histone dimers".NATURE COMMUNICATIONS 8(2017). |
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