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DOI | 10.1038/s41467-018-05515-8 |
A quiescent cell population replenishes mesenchymal stem cells to drive accelerated growth in mouse incisors | |
An, Zhengwen1; Sabalic, Maja1; Bloomquist, Ryan F.2; Fowler, Teresa E.2; Streelman, Todd2; Sharpe, Paul T.1 | |
2018-01-25 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | England; USA |
英文摘要 | The extent to which heterogeneity within mesenchymal stem cell (MSC) populations is related to function is not understood. Using the archetypal MSC in vitro surface marker, CD90/Thy1, here we show that 30% of the MSCs in the continuously growing mouse incisor express CD90/Thy1 and these cells give rise to 30% of the differentiated cell progeny during postnatal development. In adulthood, when growth rate homeostasis is established, the CD90/Thy1(+) MSCs decrease dramatically in number. When adult incisors are cut, the growth rate increases to rapidly re-establish tooth length and homeostasis. This accelerated growth rate correlates with the re-appearance of CD90/Thy(+) MSCs and re-establishment of their contribution to cell differentiation. A population of Celsr1(+) quiescent cells becomes mitotic following clipping and replenishes the CD90/Thy1 population. A sub-population of MSCs thus exists in the mouse incisor, distinguished by expression of CD90/Thy1 that plays a specific role only during periods of increased growth rate. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000423424800013 |
WOS关键词 | STROMAL CELLS ; BONE-MARROW ; DENTAL-PULP ; NICHE ; REGENERATION ; HOMEOSTASIS ; ORIGIN ; REPAIR ; TEETH |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203922 |
专题 | 资源环境科学 |
作者单位 | 1.Kings Coll London, Dent Inst, Ctr Craniofacial & Regenerat Biol, London SE1 9RT, England; 2.Georgia Inst Technol, Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA |
推荐引用方式 GB/T 7714 | An, Zhengwen,Sabalic, Maja,Bloomquist, Ryan F.,et al. A quiescent cell population replenishes mesenchymal stem cells to drive accelerated growth in mouse incisors[J]. NATURE COMMUNICATIONS,2018,9. |
APA | An, Zhengwen,Sabalic, Maja,Bloomquist, Ryan F.,Fowler, Teresa E.,Streelman, Todd,&Sharpe, Paul T..(2018).A quiescent cell population replenishes mesenchymal stem cells to drive accelerated growth in mouse incisors.NATURE COMMUNICATIONS,9. |
MLA | An, Zhengwen,et al."A quiescent cell population replenishes mesenchymal stem cells to drive accelerated growth in mouse incisors".NATURE COMMUNICATIONS 9(2018). |
条目包含的文件 | 条目无相关文件。 |
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