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DOI | 10.1038/s41467-018-05736-x |
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1 | |
Morland, Cecilie1,2,3; Andersson, Krister A.1,2,3; Haugen, Oyvind P.1; Hadzic, Alena1,2,3; Kleppa, Liv1,3; Gille, Andreas4; Rinholm, Johanne E.1,3; Palibrk, Vuk5; Diget, Elisabeth H.1,6; Kennedy, Lauritz H.1,3; Stolen, Tomas7; Hennestad, Eivind8; Moldestad, Olve9; Cai, Yiqing1; Puchades, Maja3; Offermanns, Stefan10; Vervaeke, Koen8; Bjoras, Magnar5; Wisloff, Ulrik7; Storm-Mathisen, Jon3; Bergersen, Linda H.1,3,6 | |
2017-05-23 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Norway; Germany; Denmark |
英文摘要 | Physical exercise can improve brain function and delay neurodegeneration; however, the initial signal from muscle to brain is unknown. Here we show that the lactate receptor (HCAR1) is highly enriched in pial fibroblast-like cells that line the vessels supplying blood to the brain, and in pericyte-like cells along intracerebral microvessels. Activation of HCAR1 enhances cerebral vascular endothelial growth factor A (VEGFA) and cerebral angiogenesis. High-intensity interval exercise (5 days weekly for 7 weeks), as well as L-lactate subcutaneous injection that leads to an increase in blood lactate levels similar to exercise, increases brain VEGFA protein and capillary density in wild-type mice, but not in knockout mice lacking HCAR1. In contrast, skeletal muscle shows no vascular HCAR1 expression and no HCAR1-dependent change in vascularization induced by exercise or lactate. Thus, we demonstrate that a substance released by exercising skeletal muscle induces supportive effects in brain through an identified receptor. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000401850900001 |
WOS关键词 | NEUROGENESIS ; EXPRESSION ; MODEL ; ACID ; MICE ; RAT ; PERICYTES ; LIPOLYSIS ; HYPOXIA ; HEALTH |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203949 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Oslo, Dept Oral Biol, Electron Microscopy Lab, Brain & Muscle Energy Grp, NO-0316 Oslo, Norway; 2.Oslo & Akershus Univ Coll, Fac Hlth Sci, Inst Behav Sci, NO-0167 Oslo, Norway; 3.Univ Oslo, Hlth Brain Ageing Ctr, Inst Basic Med Sci, Synapt Neurochem Lab,Div Anat,Dept Mol Med, NO-0317 Oslo, Norway; 4.Heidelberg Univ, Inst Expt & Clin Pharmacol & Toxicol, D-68169 Mannheim, Germany; 5.Norwegian Univ Sci & Technol, Dept Canc Res & Mol Med, NO-7491 Trondheim, Norway; 6.Univ Copenhagen, Fac Hlth Sci, Dept Neurosci & Pharmacol, Ctr Hlth Aging, DK-2200 Copenhagen N, Denmark; 7.Norwegian Univ Sci & Technol, Dept Circulat & Med Imaging, KG Jebsen Ctr Exercise Med, NO-7491 Trondheim, Norway; 8.Univ Oslo, Dept Physiol, Lab Neural Computat, NO-0317 Oslo, Norway; 9.Natl Hosp Norway, Oslo Univ Hosp, Ctr Rare Disorders, NO-0424 Oslo, Norway; 10.Max Planck Inst Heart & Lung Res, Dept Pharmacol, D-61231 Bad Nauheim, Germany |
推荐引用方式 GB/T 7714 | Morland, Cecilie,Andersson, Krister A.,Haugen, Oyvind P.,et al. Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Morland, Cecilie.,Andersson, Krister A..,Haugen, Oyvind P..,Hadzic, Alena.,Kleppa, Liv.,...&Bergersen, Linda H..(2017).Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1.NATURE COMMUNICATIONS,8. |
MLA | Morland, Cecilie,et al."Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1".NATURE COMMUNICATIONS 8(2017). |
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