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DOI | 10.1038/s41467-018-06168-3 |
Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage | |
Pfisterer, Simon G.1,2,3; Gateva, Gergana4; Horvath, Peter5,6; Pirhonen, Juho1,2,3; Salo, Veijo T.1,2,3; Karhinen, Leena1,2; Varjosalo, Markku4; Ryhanen, Samppa J.7,8; Lappalainen, Pekka; Ikonen, Elina1,2,3 | |
2017-03-31 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Finland; Hungary |
英文摘要 | Lipid droplets (LDs) are cellular organelles specialized in triacylglycerol (TG) storage undergoing homotypic clustering and fusion. In non-adipocytic cells with numerous LDs this is balanced by poorly understood droplet dissociation mechanisms. We identify non-muscle myosin IIa (NMIIa/MYH-9) and formin-like 1 (FMNL1) in the LD proteome. NMIIa and actin filaments concentrate around LDs, and form transient foci between dissociating LDs. NMIIa depletion results in decreased LD dissociations, enlarged LDs, decreased hydrolysis and increased storage of TGs. FMNL1 is required for actin assembly on LDs in vitro and for NMIIa recruitment to LDs in cells. We propose a novel acto-myosin structure regulating lipid storage: FMNL1-dependent assembly of myosin II-functionalized actin filaments on LDs facilitates their dissociation, thereby affecting LD surface-to-volume ratio and enzyme accessibility to TGs. In neutrophilic leucocytes from MYH9-related disease patients NMIIa inclusions are accompanied by increased lipid storage in droplets, suggesting that NMIIa dysfunction may contribute to lipid imbalance in man. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000397880600001 |
WOS关键词 | RAMAN SCATTERING MICROSCOPY ; MAMMALIAN-CELLS ; PROTEINS ; CYTOKINESIS ; RECRUITMENT ; INHIBITOR ; FUSION ; GROWTH |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203993 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Helsinki, Dept Anat, Fac Med, Helsinki 00290, Finland; 2.Univ Helsinki, Fac Med, Res Programs Unit, Helsinki 00290, Finland; 3.Minerva Fdn, Helsinki 00290, Finland; 4.Univ Helsinki, Inst Biotechnol, Helsinki 00790, Finland; 5.Univ Helsinki, Inst Mol Med Finland FIMM, FIN-00290 Helsinki, Finland; 6.Hungarian Acad Sci, Synthet & Syst Biol Unit, BRC, H-6726 Szeged, Hungary; 7.Univ Helsinki, Cent Hosp, Childrens Hosp, Div Hematol Oncol & Stem Cell Transplantat, FIN-00290 Helsinki, Finland; 8.Univ Helsinki, FIN-00290 Helsinki, Finland |
推荐引用方式 GB/T 7714 | Pfisterer, Simon G.,Gateva, Gergana,Horvath, Peter,et al. Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Pfisterer, Simon G..,Gateva, Gergana.,Horvath, Peter.,Pirhonen, Juho.,Salo, Veijo T..,...&Ikonen, Elina.(2017).Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage.NATURE COMMUNICATIONS,8. |
MLA | Pfisterer, Simon G.,et al."Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage".NATURE COMMUNICATIONS 8(2017). |
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