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DOI | 10.1038/s41467-018-06432-6 |
Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives | |
Vishwakarma, Medhavi1,2; Di Russo, Jacopo1,2; Probst, Dimitri3; Schwarz, Ulrich S.3; Das, Tamal1,2,4; Spatz, Joachim P.1,2 | |
2018-08-27 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; India |
英文摘要 | Regulating the emergence of leaders is a central aspect of collective cell migration, but the underlying mechanisms remain ambiguous. Here we show that the selective emergence of leader cells at the epithelial wound-margin depends on the dynamics of the follower cells and is spatially limited by the length-scale of collective force transduction. Owing to the dynamic heterogeneity of the monolayer, cells behind the prospective leaders manifest locally increased traction and monolayer stresses much before these leaders display any phenotypic traits. Followers, in turn, pull on the future leaders to elect them to their fate. Once formed, the territory of a leader can extend only to the length up-to which forces are correlated, which is similar to the length up-to which leader cells can transmit forces. These findings provide mechanobiological insight into the hierarchy in cell collectives during epithelial wound healing. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000442790800003 |
WOS关键词 | FORCE MICROSCOPY ; BORDER CELLS ; GUIDANCE ; CANCER ; MORPHOGENESIS ; TRANSITION ; DYNAMICS ; INVASION ; TISSUES ; MODEL |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204005 |
专题 | 资源环境科学 |
作者单位 | 1.Max Planck Inst Med Res, Dept Cellular Biophys, Jahnstr 29, D-69120 Heidelberg, Germany; 2.Heidelberg Univ, Dept Biophys Chem, INF 253, D-69120 Heidelberg, Germany; 3.Heidelberg Univ, Inst Theoret Phys & BioQuant, INF 267, D-69120 Heidelberg, Germany; 4.Tata Inst Fundamental Res Hyderabad, TIFR Ctr Interdisciplinary Sci TCIS, Hyderabad 500107, India |
推荐引用方式 GB/T 7714 | Vishwakarma, Medhavi,Di Russo, Jacopo,Probst, Dimitri,et al. Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Vishwakarma, Medhavi,Di Russo, Jacopo,Probst, Dimitri,Schwarz, Ulrich S.,Das, Tamal,&Spatz, Joachim P..(2018).Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives.NATURE COMMUNICATIONS,9. |
MLA | Vishwakarma, Medhavi,et al."Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives".NATURE COMMUNICATIONS 9(2018). |
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