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DOI | 10.1038/s41467-018-06732-x |
Modulation of anti-tumor immunity by the brain's reward system | |
Ben-Shaanan, Tamar L.1,2,3; Schiller, Maya1,2,3; Azulay-Debby, Hilla1,2,3; Korin, Ben1,2,3; Boshnak, Nadia1,2,3; Koren, Tamar1,2,3; Krot, Maria1,2,3; Shakya, Jivan1,4; Rahat, Michal A.1,4; Hakim, Fahed1,5,6; Rolls, Asya1,2,3 | |
2018-07-13 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Israel |
英文摘要 | Regulating immunity is a leading target for cancer therapy. Here, we show that the anti-tumor immune response can be modulated by the brain's reward system, a key circuitry in emotional processes. Activation of the reward system in tumor-bearing mice (Lewis lung carcinoma (LLC) and B16 melanoma) using chemogenetics (DREADDs), resulted in reduced tumor weight. This effect was mediated via the sympathetic nervous system (SNS), manifested by an attenuated noradrenergic input to a major immunological site, the bone marrow. Myeloid derived suppressor cells (MDSCs), which develop in the bone marrow, became less immunosuppressive following reward system activation. By depleting or adoptively transferring the MDSCs, we demonstrated that these cells are both necessary and sufficient to mediate reward system effects on tumor growth. Given the central role of the reward system in positive emotions, these findings introduce a physiological mechanism whereby the patient's psychological state can impact anti-tumor immunity and cancer progression. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000438494900002 |
WOS关键词 | TUMOR-NECROSIS-FACTOR ; TYROSINE-HYDROXYLASE ; SUPPRESSOR-CELLS ; BREAST-CANCER ; DOPAMINERGIC-NEURONS ; ADAPTIVE IMMUNITY ; BONE-MARROW ; SURVIVAL ; MICROENVIRONMENT ; MYELOPOIESIS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204039 |
专题 | 资源环境科学 |
作者单位 | 1.Technion Israel Inst Technol, Dept Immunol, Rappaport Fac Med, IL-3525422 Haifa, Israel; 2.Technion Israel Inst Technol, Dept Neurosci, Rappaport Fac Med, IL-3525422 Haifa, Israel; 3.Technion Israel Inst Technol, Technion Integrated Canc Ctr, IL-3525422 Haifa, Israel; 4.Carmel Hosp, Immunotherapy Lab, IL-3436212 Haifa, Israel; 5.Pediat Pulm Unit, Rambam Hlth Care Campus, IL-3109601 Haifa, Israel; 6.EMMS Hosp, Canc Res Ctr, IL-16100 Nazareth, Israel |
推荐引用方式 GB/T 7714 | Ben-Shaanan, Tamar L.,Schiller, Maya,Azulay-Debby, Hilla,et al. Modulation of anti-tumor immunity by the brain's reward system[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Ben-Shaanan, Tamar L..,Schiller, Maya.,Azulay-Debby, Hilla.,Korin, Ben.,Boshnak, Nadia.,...&Rolls, Asya.(2018).Modulation of anti-tumor immunity by the brain's reward system.NATURE COMMUNICATIONS,9. |
MLA | Ben-Shaanan, Tamar L.,et al."Modulation of anti-tumor immunity by the brain's reward system".NATURE COMMUNICATIONS 9(2018). |
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