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DOI | 10.1038/s41467-018-07087-z |
A mobile endocytic network connects clathrinin-dependent receptor endocytosis to recycling and promotes T cell activation | |
Compeer, Ewoud B.1,2,5; Kraus, Felix1,2,6; Ecker, Manuela1,2; Redpath, Gregory1,2; Amiezer, Mayan1,2,7; Rother, Nils1,2,8; Nicovich, Philip R.1,2; Kapoor-Kaushik, Natasha1,2; Deng, Qiji1,2; Samson, Guerric P. B.3; Yang, Zhengmin1,2; Lou, Jieqiong1,2; Carnell, Michael4; Vartoukian, Haig1,2; Gaus, Katharina1,2; Rossy, Jeremie1,2,3 | |
2018-04-23 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Australia; Switzerland; England; Netherlands |
英文摘要 | Endocytosis of surface receptors and their polarized recycling back to the plasma membrane are central to many cellular processes, such as cell migration, cytokinesis, basolateral polarity of epithelial cells and T cell activation. Little is known about the mechanisms that control the organization of recycling endosomes and how they connect to receptor endocytosis. Here, we follow the endocytic journey of the T cell receptor (TCR), from internalization at the plasma membrane to recycling back to the immunological synapse. We show that TCR triggering leads to its rapid uptake through a clathrin-independent pathway. Immediately after internalization, TCR is incorporated into a mobile and long-lived endocytic network demarked by the membrane-organizing proteins flotillins. Although flotillins are not required for TCR internalization, they are necessary for its recycling to the immunological synapse. We further show that flotillins are essential for T cell activation, supporting TCR nanoscale organization and signaling. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000430541900013 |
WOS关键词 | IMMUNOLOGICAL SYNAPSE ; PLASMA-MEMBRANE ; PROTEINS ; DYNAMICS ; INTERNALIZATION ; TRAFFICKING ; CARGO ; REGGIE-1/FLOTILLIN-2 ; OLIGOMERIZATION ; FLOTILLIN-1 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204059 |
专题 | 资源环境科学 |
作者单位 | 1.Univ New South Wales, EMBL Australia Node Single Mol Sci, Sch Med Sci, High St Gate 9, Sydney, NSW 2052, Australia; 2.Univ New South Wales, ARC Ctr Excellence Adv Mol Imaging, High St Gate 9, Sydney, NSW 2052, Australia; 3.Univ Konstanz, Biotechnol Inst Thurgau, CH-8280 Kreuzlingen, Switzerland; 4.Univ New South Wales, Biomed Imaging Facil, High St Gate 9, Sydney, NSW 2052, Australia; 5.Univ Oxford, Kennedy Inst Rheumatol, Roosevelt Dr, Oxford OX3 7FY, England; 6.Monash Univ, Dept Biochem & Mol Biol, 23 Innovat Walk, Melbourne, Vic 3800, Australia; 7.Garvan Inst Med Res, 384 Victoria St, Darlinghurst, NSW 2010, Australia; 8.Radboud Univ Nijmegen, Med Ctr, Dept Nephrol, Geert Grootepl 10, NL-6525 GA Nijmegen, Netherlands |
推荐引用方式 GB/T 7714 | Compeer, Ewoud B.,Kraus, Felix,Ecker, Manuela,et al. A mobile endocytic network connects clathrinin-dependent receptor endocytosis to recycling and promotes T cell activation[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Compeer, Ewoud B..,Kraus, Felix.,Ecker, Manuela.,Redpath, Gregory.,Amiezer, Mayan.,...&Rossy, Jeremie.(2018).A mobile endocytic network connects clathrinin-dependent receptor endocytosis to recycling and promotes T cell activation.NATURE COMMUNICATIONS,9. |
MLA | Compeer, Ewoud B.,et al."A mobile endocytic network connects clathrinin-dependent receptor endocytosis to recycling and promotes T cell activation".NATURE COMMUNICATIONS 9(2018). |
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