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DOI10.1038/s41467-018-07087-z
A mobile endocytic network connects clathrinin-dependent receptor endocytosis to recycling and promotes T cell activation
Compeer, Ewoud B.1,2,5; Kraus, Felix1,2,6; Ecker, Manuela1,2; Redpath, Gregory1,2; Amiezer, Mayan1,2,7; Rother, Nils1,2,8; Nicovich, Philip R.1,2; Kapoor-Kaushik, Natasha1,2; Deng, Qiji1,2; Samson, Guerric P. B.3; Yang, Zhengmin1,2; Lou, Jieqiong1,2; Carnell, Michael4; Vartoukian, Haig1,2; Gaus, Katharina1,2; Rossy, Jeremie1,2,3
2018-04-23
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
出版年2018
卷号9
文章类型Article
语种英语
国家Australia; Switzerland; England; Netherlands
英文摘要

Endocytosis of surface receptors and their polarized recycling back to the plasma membrane are central to many cellular processes, such as cell migration, cytokinesis, basolateral polarity of epithelial cells and T cell activation. Little is known about the mechanisms that control the organization of recycling endosomes and how they connect to receptor endocytosis. Here, we follow the endocytic journey of the T cell receptor (TCR), from internalization at the plasma membrane to recycling back to the immunological synapse. We show that TCR triggering leads to its rapid uptake through a clathrin-independent pathway. Immediately after internalization, TCR is incorporated into a mobile and long-lived endocytic network demarked by the membrane-organizing proteins flotillins. Although flotillins are not required for TCR internalization, they are necessary for its recycling to the immunological synapse. We further show that flotillins are essential for T cell activation, supporting TCR nanoscale organization and signaling.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000430541900013
WOS关键词IMMUNOLOGICAL SYNAPSE ; PLASMA-MEMBRANE ; PROTEINS ; DYNAMICS ; INTERNALIZATION ; TRAFFICKING ; CARGO ; REGGIE-1/FLOTILLIN-2 ; OLIGOMERIZATION ; FLOTILLIN-1
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/204059
专题资源环境科学
作者单位1.Univ New South Wales, EMBL Australia Node Single Mol Sci, Sch Med Sci, High St Gate 9, Sydney, NSW 2052, Australia;
2.Univ New South Wales, ARC Ctr Excellence Adv Mol Imaging, High St Gate 9, Sydney, NSW 2052, Australia;
3.Univ Konstanz, Biotechnol Inst Thurgau, CH-8280 Kreuzlingen, Switzerland;
4.Univ New South Wales, Biomed Imaging Facil, High St Gate 9, Sydney, NSW 2052, Australia;
5.Univ Oxford, Kennedy Inst Rheumatol, Roosevelt Dr, Oxford OX3 7FY, England;
6.Monash Univ, Dept Biochem & Mol Biol, 23 Innovat Walk, Melbourne, Vic 3800, Australia;
7.Garvan Inst Med Res, 384 Victoria St, Darlinghurst, NSW 2010, Australia;
8.Radboud Univ Nijmegen, Med Ctr, Dept Nephrol, Geert Grootepl 10, NL-6525 GA Nijmegen, Netherlands
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GB/T 7714
Compeer, Ewoud B.,Kraus, Felix,Ecker, Manuela,et al. A mobile endocytic network connects clathrinin-dependent receptor endocytosis to recycling and promotes T cell activation[J]. NATURE COMMUNICATIONS,2018,9.
APA Compeer, Ewoud B..,Kraus, Felix.,Ecker, Manuela.,Redpath, Gregory.,Amiezer, Mayan.,...&Rossy, Jeremie.(2018).A mobile endocytic network connects clathrinin-dependent receptor endocytosis to recycling and promotes T cell activation.NATURE COMMUNICATIONS,9.
MLA Compeer, Ewoud B.,et al."A mobile endocytic network connects clathrinin-dependent receptor endocytosis to recycling and promotes T cell activation".NATURE COMMUNICATIONS 9(2018).
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