Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-018-07211-z |
Age structure landscapes emerge from the equilibrium between aging and rejuvenation in bacterial populations | |
Proenca, Audrey M.1,2; Rang, Camilla Ulla1; Buetz, Christen1; Shi, Chao1; Chao, Lin1 | |
2018-09-13 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Brazil |
英文摘要 | The physiological asymmetry between daughters of a mother bacterium is produced by the inheritance of either old poles, carrying non-genetic damage, or newly synthesized poles. However, as bacteria display long-term growth stability leading to physiological immortality, there is controversy on whether asymmetry corresponds to aging. Here we show that deterministic age structure landscapes emerge from physiologically immortal bacterial lineages. Through single-cell microscopy and microfluidic techniques, we demonstrate that aging and rejuvenating bacterial lineages reach two distinct states of growth equilibria. These equilibria display stabilizing properties, which we quantified according to the compensatory trajectories of continuous lineages throughout generations. Finally, we show that the physiological asymmetry between aging and rejuvenating lineages produces complex age structure landscapes, resulting in a deterministic phenotypic heterogeneity that is neither an artifact of starvation nor a product of extrinsic damage. These findings indicate that physiological immortality and cellular aging can both be manifested in single celled organisms. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000444494800006 |
WOS关键词 | ASYMMETRIC SEGREGATION ; ESCHERICHIA-COLI ; DIVISION ; PROTEINS ; DYNAMICS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204084 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Calif San Diego, Div Biol Sci, Sect Ecol Behav & Evolut, La Jolla, CA 92093 USA; 2.Minist Educ Brazil, CAPES Fdn, BR-70040020 Brasilia, DF, Brazil |
推荐引用方式 GB/T 7714 | Proenca, Audrey M.,Rang, Camilla Ulla,Buetz, Christen,et al. Age structure landscapes emerge from the equilibrium between aging and rejuvenation in bacterial populations[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Proenca, Audrey M.,Rang, Camilla Ulla,Buetz, Christen,Shi, Chao,&Chao, Lin.(2018).Age structure landscapes emerge from the equilibrium between aging and rejuvenation in bacterial populations.NATURE COMMUNICATIONS,9. |
MLA | Proenca, Audrey M.,et al."Age structure landscapes emerge from the equilibrium between aging and rejuvenation in bacterial populations".NATURE COMMUNICATIONS 9(2018). |
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