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DOI | 10.1038/s41467-018-07623-x |
KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling | |
Schou, Kenneth B.1; Mogensen, Johanne B.1; Morthorst, Stine K.1; Nielsen, Brian S.1,5; Aleliunaite, Aiste1,6; Serra-Marques, Andrea2,7; Furstenberg, Nicoline1; Saunier, Sophie3,4; Bizet, Albane A.3,4; Veland, Iben R.1,8; Akhmanova, Anna2; Christensen, Soren T.1; Pedersen, Lotte B.1 | |
2017-01-30 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Denmark; Netherlands; France; USA |
英文摘要 | Ciliary membrane composition is controlled by transition zone (TZ) proteins such as RPGRIP1, RPGRIPL and NPHP4, which are vital for balanced coordination of diverse signalling systems like the Sonic hedgehog (Shh) pathway. Activation of this pathway involves Shh-induced ciliary accumulation of Smoothened (SMO), which is disrupted by disease-causing mutations in TZ components. Here we identify kinesin-3 motor protein KIF13B as a novel member of the RPGRIP1N-C2 domain-containing protein family and show that KIF13B regulates TZ membrane composition and ciliary SMO accumulation. KIF13B is upregulated during ciliogenesis and is recruited to the ciliary base by NPHP4, which binds to two distinct sites in the KIF13B tail region, including an RPGRIP1N-C2 domain. KIF13B and NPHP4 are both essential for establishment of a CAV1 membrane microdomain at the TZ, which in turn is required for Shh-induced ciliary SMO accumulation. Thus KIF13B is a novel regulator of ciliary TZ configuration, membrane composition and Shh signalling. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000392858600001 |
WOS关键词 | MEMBRANE-PROTEIN ENTRY ; PRIMARY CILIUM ; CELLS ; NEPHROCYSTIN-4 ; KINESIN ; PATHWAY ; COMPLEX ; IFT ; COMPARTMENTALIZATION ; MORPHOGENESIS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204117 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Copenhagen, Sect Cell Biol & Physiol, Dept Biol, August Krogh Bldg,Univ Pk 13, DK-2100 Copenhagen OE, Denmark; 2.Univ Utrecht, Fac Sci, Dept Biol, Cell Biol, Padualaan 8, NL-3584 CH Utrecht, Netherlands; 3.INSERM, Lab Hereditary Kidney Dis, UMR 1163, F-75015 Paris, France; 4.Paris Descartes Sorbonne Paris Cite Univ, Imagine Inst, F-75015 Paris, France; 5.Univ Copenhagen, Dept Neurosci & Pharmacol, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark; 6.Univ Copenhagen, Dept Cellular & Mol Med, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark; 7.Univ Calif San Francisco, Dept Cell & Tissue Biol, 513 Parnassus Ave, San Francisco, CA 94143 USA; 8.Univ Copenhagen, Dept Hlth & Med Sci, Biotech Res & Innovat Ctr, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark |
推荐引用方式 GB/T 7714 | Schou, Kenneth B.,Mogensen, Johanne B.,Morthorst, Stine K.,et al. KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Schou, Kenneth B..,Mogensen, Johanne B..,Morthorst, Stine K..,Nielsen, Brian S..,Aleliunaite, Aiste.,...&Pedersen, Lotte B..(2017).KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.NATURE COMMUNICATIONS,8. |
MLA | Schou, Kenneth B.,et al."KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling".NATURE COMMUNICATIONS 8(2017). |
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