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DOI | 10.1038/s41467-018-07936-x |
Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias | |
Jungen, Christiane1,2; Scherschel, Katharina1,2; Eickholt, Christian1; Kuklik, Pawel1; Klatt, Niklas1,2; Bork, Nadja2,3; Salzbrunn, Tim1; Alken, Fares1; Angendohr, Stephan1; Klene, Christiane4; Mester, Janos4; Kloecker, Nikolaj5; Veldkamp, Marieke W.6; Schumacher, Udo7; Willems, Stephan1,2; Nikolaev, Viacheslav O.2,3; Meyer, Christian1,2 | |
2019-01-08 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; Netherlands |
英文摘要 | The parasympathetic nervous system plays an important role in the pathophysiology of atrial fibrillation. Catheter ablation, a minimally invasive procedure deactivating abnormal firing cardiac tissue, is increasingly becoming the therapy of choice for atrial fibrillation. This is inevitably associated with the obliteration of cardiac cholinergic neurons. However, the impact on ventricular electrophysiology is unclear. Here we show that cardiac cholinergic neurons modulate ventricular electrophysiology. Mechanical disruption or pharmacological blockade of parasympathetic innervation shortens ventricular refractory periods, increases the incidence of ventricular arrhythmia and decreases ventricular cAMP levels in murine hearts. Immunohistochemistry confirmed ventricular cholinergic innervation, revealing parasympathetic fibres running from the atria to the ventricles parallel to sympathetic fibres. In humans, catheter ablation of atrial fibrillation, which is accompanied by accidental parasympathetic and concomitant sympathetic denervation, raises the burden of premature ventricular complexes. In summary, our results demonstrate an influence of cardiac cholinergic neurons on the regulation of ventricular function and arrhythmogenesis. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000427496700001 |
WOS关键词 | PAROXYSMAL ATRIAL-FIBRILLATION ; HEART-RATE-VARIABILITY ; PULMONARY VEIN ISOLATION ; NERVE-STIMULATION ; PARASYMPATHETIC INNERVATION ; AUTONOMIC DENERVATION ; TACHYCARDIA ; DISEASE ; RABBIT ; RHYTHM |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204148 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Hosp Hamburg Eppendorf, Univ Heart Ctr, Dept Cardiol Electrophysiol, Cardiac Neuro & Electrophysiol Res Grp cNEP, Martinistr 52, D-20246 Hamburg, Germany; 2.DZHK German Ctr Cardiovasc Res, Partner Site Hamburg Kiel Lubeck, D-13347 Berlin, Germany; 3.Univ Med Ctr Hamburg Eppendorf, Inst Expt Cardiovasc Res, Martinistr 52, D-20246 Hamburg, Germany; 4.Univ Med Ctr Hamburg Eppendorf, Dept Nucl Med, Martinistr 52, D-20246 Hamburg, Germany; 5.Univ Dusseldorf, Med Fac, Inst Neural & Sensory Physiol, Univ Str 1, D-40225 Dusseldorf, Germany; 6.Univ Amsterdam, Acad Med Ctr, Dept Clin & Expt Cardiol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands; 7.Univ Med Ctr Hamburg Eppendorf, Univ Canc Ctr Hamburg, Inst Anat & Expt Morphol, Martinistr 52, D-20246 Hamburg, Germany |
推荐引用方式 GB/T 7714 | Jungen, Christiane,Scherschel, Katharina,Eickholt, Christian,et al. Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Jungen, Christiane.,Scherschel, Katharina.,Eickholt, Christian.,Kuklik, Pawel.,Klatt, Niklas.,...&Meyer, Christian.(2019).Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias.NATURE COMMUNICATIONS,8. |
MLA | Jungen, Christiane,et al."Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias".NATURE COMMUNICATIONS 8(2019). |
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