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DOI | 10.1038/s41467-018-08257-9 |
Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer | |
Carstens, Julienne L.1; de Sampaio, Pedro Correa1; Yang, Dalu2,3; Barua, Souptik2,3; Wang, Huamin4; Rao, Arvind2,3,5; Allison, James P.6; LeBleu, Valerie S.1; Kalluri, Raghu1,7,8 | |
2019-01-21 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The exact nature and dynamics of pancreatic ductal adenocarcinoma (PDAC) immune composition remains largely unknown. Desmoplasia is suggested to polarize PDAC immunity. Therefore, a comprehensive evaluation of the composition and distribution of desmoplastic elements and T-cell infiltration is necessary to delineate their roles. Here we develop a novel computational imaging technology for the simultaneous evaluation of eight distinct markers, allowing for spatial analysis of distinct populations within the same section. We report a heterogeneous population of infiltrating T lymphocytes. Spatial distribution of cytotoxic Tcells in proximity to cancer cells correlates with increased overall patient survival. Collagen-I and alpha SMA(+) fibroblasts do not correlate with paucity in T-cell accumulation, suggesting that PDAC desmoplasia may not be a simple physical barrier. Further exploration of this technology may improve our understanding of how specific stromal composition could impact T-cell activity, with potential impact on the optimization of immune-modulatory therapies. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000400155900001 |
WOS关键词 | TUMOR MICROENVIRONMENT ; DUCTAL ADENOCARCINOMA ; IMMUNOTHERAPY ; CARCINOMA ; BLOCKADE ; INFILTRATION ; FIBROBLASTS ; RESISTANCE ; IMMUNITY ; PD-1 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204178 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Metastasis Res Ctr, Houston, TX 77030 USA; 2.Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA; 3.Rice Univ, Dept Elect & Comp Engn, Houston, TX 77005 USA; 4.Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA; 5.Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA; 6.Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA; 7.Rice Univ, Dept Bioengn, Houston, TX 77005 USA; 8.Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA |
推荐引用方式 GB/T 7714 | Carstens, Julienne L.,de Sampaio, Pedro Correa,Yang, Dalu,et al. Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Carstens, Julienne L..,de Sampaio, Pedro Correa.,Yang, Dalu.,Barua, Souptik.,Wang, Huamin.,...&Kalluri, Raghu.(2019).Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer.NATURE COMMUNICATIONS,8. |
MLA | Carstens, Julienne L.,et al."Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer".NATURE COMMUNICATIONS 8(2019). |
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