Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-019-08316-9 |
Genome-scale metabolic reconstructions of multiple Salmonella strains reveal serovar-specific metabolic traits | |
Seif, Yara1; Kavvas, Erol1; Lachance, Jean-Christophe2; Yurkovich, James T.1,3; Nuccio, Sean-Paul4; Fang, Xin1; Catoiu, Edward1; Raffatellu, Manuela4; Palsson, Bernhard O.1,3,4,5; Monk, Jonathan M.1 | |
2019-01-24 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Canada; Denmark |
英文摘要 | Salmonella strains are traditionally classified into serovars based on their surface antigens. While increasing availability of whole-genome sequences has allowed for more detailed subtyping of strains, links between genotype, serovar, and host remain elusive. Here we reconstruct genome-scale metabolic models for 410 Salmonella strains spanning 64 serovars. Model-predicted growth capabilities in over 530 different environments demonstrate that: (1) the Salmonella accessory metabolic network includes alternative carbon metabolism, and cell wall biosynthesis; (2) metabolic capabilities correspond to each strain's serovar and isolation host; (3) growth predictions agree with 83.1% of experimental outcomes for 12 strains (690 out of 858); (4) 27 strains are auxotrophic for at least one compound, including L-tryptophan, niacin, L-histidine, L-cysteine, and p-aminobenzoate; and (5) the catabolic pathways that are important for fitness in the gastrointestinal environment are lost amongst extraintestinal serovars. Our results reveal growth differences that may reflect adaptation to particular colonization sites. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000444556500002 |
WOS关键词 | STRUCTURAL DIVERSITY ; GLOBAL BURDEN ; PATHOGENICITY ; EVOLUTION ; ENTERICA ; CAPABILITIES ; TYPHIMURIUM ; SEQUENCES ; ANTIGENS ; MODELS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204183 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA; 2.Univ Sherbrooke, Dept Biol, Sherbrooke, PQ, Canada; 3.Univ Calif San Diego, Bioinformat & Syst Biol Program, La Jolla, CA 92093 USA; 4.Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA; 5.Tech Univ Denmark, Novo Nordisk Fdn, Ctr Biosustainabil, Bldg 220, DK-2800 Lyngby, Denmark |
推荐引用方式 GB/T 7714 | Seif, Yara,Kavvas, Erol,Lachance, Jean-Christophe,et al. Genome-scale metabolic reconstructions of multiple Salmonella strains reveal serovar-specific metabolic traits[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Seif, Yara.,Kavvas, Erol.,Lachance, Jean-Christophe.,Yurkovich, James T..,Nuccio, Sean-Paul.,...&Monk, Jonathan M..(2019).Genome-scale metabolic reconstructions of multiple Salmonella strains reveal serovar-specific metabolic traits.NATURE COMMUNICATIONS,9. |
MLA | Seif, Yara,et al."Genome-scale metabolic reconstructions of multiple Salmonella strains reveal serovar-specific metabolic traits".NATURE COMMUNICATIONS 9(2019). |
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