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DOI | 10.1038/s41467-019-08406-8 |
Genomic innovations linked to infection strategies across emerging pathogenic chytrid fungi | |
Farrer, Rhys A.1,2; Martel, An3; Verbrugghe, Elin3; Abouelleil, Amr1; Ducatelle, Richard3; Longcore, Joyce E.4; James, Timothy Y.5; Pasmans, Frank3; Fisher, Matthew C.2; Cuomo, Christina A.1 | |
2019-01-28 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; England; Belgium |
英文摘要 | To understand the evolutionary pathways that lead to emerging infections of vertebrates, here we explore the genomic innovations that allow free-living chytrid fungi to adapt to and colonize amphibian hosts. Sequencing and comparing the genomes of two pathogenic species of Batrachochytrium to those of close saprophytic relatives reveals that pathogenicity is associated with remarkable expansions of protease and cell wall gene families, while divergent infection strategies are linked to radiations of lineage-specific gene families. By comparing the host-pathogen response to infection for both pathogens, we illuminate the traits that underpin a strikingly different immune response within a shared host species. Our results show that, despite commonalities that promote infection, specific gene-family radiations contribute to distinct infection strategies. The breadth and evolutionary novelty of candidate virulence factors that we discover underscores the urgent need to halt the advance of pathogenic chytrids and prevent incipient loss of biodiversity. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000396856000001 |
WOS关键词 | PROTEIN ; CHYTRIDIOMYCOSIS ; ANNOTATION ; ALIGNMENT ; AMPHIBIANS ; EFFECTORS ; HOST ; TOOL ; IDENTIFICATION ; PREDICTION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204188 |
专题 | 资源环境科学 |
作者单位 | 1.Broad Inst MIT & Harvard, Genome Sequencing & Anal Program, Cambridge, MA 02142 USA; 2.Imperial Coll London, Sch Publ Hlth, Dept Infect Dis Epidemiol, London W2 1PG, England; 3.Univ Ghent, Fac Vet Med, Dept Pathol Bacteriol & Avian Dis, Salisburylaan 133, B-9820 Merelbeke, Belgium; 4.Univ Maine, Sch Biol & Ecol, Orono, ME 04469 USA; 5.Univ Michigan, Dept Ecol & Evolutionary Biol, Ann Arbor, MI 48109 USA |
推荐引用方式 GB/T 7714 | Farrer, Rhys A.,Martel, An,Verbrugghe, Elin,et al. Genomic innovations linked to infection strategies across emerging pathogenic chytrid fungi[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Farrer, Rhys A..,Martel, An.,Verbrugghe, Elin.,Abouelleil, Amr.,Ducatelle, Richard.,...&Cuomo, Christina A..(2019).Genomic innovations linked to infection strategies across emerging pathogenic chytrid fungi.NATURE COMMUNICATIONS,8. |
MLA | Farrer, Rhys A.,et al."Genomic innovations linked to infection strategies across emerging pathogenic chytrid fungi".NATURE COMMUNICATIONS 8(2019). |
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