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DOI | 10.1038/s41467-019-08408-6 |
IL-15 sustains IL-7R-independent ILC2 and ILC3 development | |
Robinette, Michelle L.; Bando, Jennifer K.; Song, Wilbur; Ulland, Tyler K.; Gilfillan, Susan; Colonna, Marco | |
2019-02-04 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The signals that maintain tissue-resident innate lymphoid cells (ILC) in different microenvironments are incompletely understood. Here we show that IL-7 receptor (IL-7R) is not strictly required for the development of any ILC subset, as residual cells persist in the small intestinal lamina propria (siLP) of adult and neonatal Il7ra(-/-) mice. Il7ra(-/-) ILC2 primarily express an ST2(-) phenotype, but are not inflammatory ILC2. CCR6(+) ILC3, which express higher Bcl-2 than other ILC3, are the most abundant subset in Il7ra(-/-) siLP. All ILC subsets are functionally competent in vitro, and are sufficient to provide enhanced protection to infection with C. rodentium. IL-15 equally sustains wild-type and Il7ra(-/-) ILC survival in vitro and compensates for IL-7R deficiency, as residual ILCs are depleted in mice lacking both molecules. Collectively, these data demonstrate that siLP ILCs are not completely IL-7R dependent, but can persist partially through IL-15 signalling. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000397879900001 |
WOS关键词 | INNATE LYMPHOID-CELLS ; T-CELLS ; NATURAL-KILLER ; TUFT CELLS ; HOMEOSTASIS ; MICE ; DIFFERENTIATION ; EXPRESSION ; IMMUNITY ; MEMORY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204202 |
专题 | 资源环境科学 |
作者单位 | Washington Univ, Sch Med, Dept Pathol & Immunol, 509 S Euclid Ave Box 8118, St Louis, MO 63110 USA |
推荐引用方式 GB/T 7714 | Robinette, Michelle L.,Bando, Jennifer K.,Song, Wilbur,et al. IL-15 sustains IL-7R-independent ILC2 and ILC3 development[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Robinette, Michelle L.,Bando, Jennifer K.,Song, Wilbur,Ulland, Tyler K.,Gilfillan, Susan,&Colonna, Marco.(2019).IL-15 sustains IL-7R-independent ILC2 and ILC3 development.NATURE COMMUNICATIONS,8. |
MLA | Robinette, Michelle L.,et al."IL-15 sustains IL-7R-independent ILC2 and ILC3 development".NATURE COMMUNICATIONS 8(2019). |
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