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DOI | 10.1038/s41467-019-08347-2 |
Molecular definition of group 1 innate lymphoid cells in the mouse uterus | |
Filipovic, Iva1,2,3; Chiossone, Laura4,10; Vacca, Paola5,6,7; Hamilton, Russell S.3; Ingegnere, Tiziano7; Doisne, Jean-Marc1,11; Hawkes, Delia A.1; Mingari, Maria Cristina5,6,8; Sharkey, Andrew M.3,9; Moretta, Lorenzo7; Colucci, Francesco1,3 | |
2019-02-06 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | England; Italy; France |
英文摘要 | Determining the function of uterine lymphocytes is challenging because of the dynamic changes in response to sex hormones and, during pregnancy, to the invading foetal trophoblast cells. Here we provide a genome-wide transcriptome atlas of mouse uterine group 1 innate lymphoid cells (ILCs) at mid-gestation. Tissue-resident Eomes(+)CD49a(+) NK cells (trNK), which resemble human uterine NK cells, are most abundant during early pregnancy, and have gene signatures associated with TGF-beta responses and interactions with trophoblast, epithelial, endothelial, smooth muscle cells, leucocytes and extracellular matrix. Conventional NK cells expand late in gestation and may engage in crosstalk with trNK cells involving IL-18 and IFN-gamma. Eomes(-)CD49a(+) ILC1s dominate before puberty, and specifically expand in second pregnancies when the expression of the memory cell marker CXCR6 is upregulated. These results identify trNK cells as the cellular hub of uterine group 1 ILCs, and mark CXCR6(+) ILC1s as potential memory cells of pregnancy. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000448575400001 |
WOS关键词 | UTERINE NK CELLS ; CHEMOKINE RECEPTOR CXCR6 ; FATTY-ACID SYNTHESIS ; DECIDUAL NK ; MATERNAL KIR ; B-CELLS ; EXPRESSION ; MEMORY ; LIVER ; INFLAMMATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204203 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Cambridge, Dept Obstet & Gynaecol, NIHR Cambridge Biomed Res Ctr, Sch Clin Med, Cambridge CB2 0SW, England; 2.Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3EG, England; 3.Univ Cambridge, Ctr Trophoblast Res, Cambridge CB2 3EG, England; 4.G Gaslini Inst Children, Genoa, Italy; 5.Policlin San Martino IRCCS Oncol, I-16132 Genoa, Italy; 6.Univ Genoa, Dept Expt Med DIMES, I-16132 Genoa, Italy; 7.IRCCS Bambino Gesu Childrens Hosp, Dept Immunol, I-00165 Rome, Italy; 8.Univ Genoa, CEBR, I-16132 Genoa, Italy; 9.Univ Cambridge, Dept Pathol, Tennis Court Rd, Cambridge CB2 1QP, England; 10.Innate Pharma, Innate Pharma Res Labs, F-13009 Marseille, France; 11.Pasteur Inst, Dept Immunol, F-75015 Paris, France |
推荐引用方式 GB/T 7714 | Filipovic, Iva,Chiossone, Laura,Vacca, Paola,et al. Molecular definition of group 1 innate lymphoid cells in the mouse uterus[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Filipovic, Iva.,Chiossone, Laura.,Vacca, Paola.,Hamilton, Russell S..,Ingegnere, Tiziano.,...&Colucci, Francesco.(2019).Molecular definition of group 1 innate lymphoid cells in the mouse uterus.NATURE COMMUNICATIONS,9. |
MLA | Filipovic, Iva,et al."Molecular definition of group 1 innate lymphoid cells in the mouse uterus".NATURE COMMUNICATIONS 9(2019). |
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