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DOI | 10.1038/s41467-019-08636-w |
Reviving the Weizmann process for commercial n-butanol production | |
Ngoc-Phuong-Thao Nguyen1,2,3,4; Raynaud, Celine5; Meynial-Salles, Isabelle1,2,3; Soucaille, Philippe1,2,3,5,6 | |
2019-02-12 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | France; Vietnam; England |
英文摘要 | Developing a commercial process for the biological production of n-butanol is challenging as it needs to combine high titer, yield, and productivities. Here we engineer Clostridium acetobutylicum to stably and continuously produce n-butanol on a mineral media with glucose as sole carbon source. We further design a continuous process for fermentation of high concentration glucose syrup using in situ extraction of alcohols by distillation under low pressure and high cell density cultures to increase the titer, yield, and productivity of n-butanol production to the level of 550 g/L, 0.35 g/g, and 14 g/L/hr, respectively. This process provides a mean to produce n-butanol at performance levels comparable to that of corn wet milling ethanol plants using yeast as a biocatalyst. It may hold the potential to be scaled-up at pilot and industrial levels for the commercial production of n-butanol. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000444282600004 |
WOS关键词 | ACETOBUTYLICUM ATCC 824 ; CLOSTRIDIUM-ACETOBUTYLICUM ; ESCHERICHIA-COLI ; METABOLIC FLEXIBILITY ; KINASE GENES ; FERMENTATION ; BUTYRATE ; THIOLASE ; EXPRESSION ; TOLERANCE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204215 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Toulouse, INSA, UPS, INP,LISBP, Toulouse, France; 2.INRA, UMR792, Toulouse, France; 3.CNRS, UMR5504, Toulouse, France; 4.Tan Tao Univ, Sch Med, Tan Duc E City, Long An, Vietnam; 5.Biopole Clermont Limagne, Metab Explorer, St Beauzire, France; 6.Univ Nottingham, Sch Life Sci, BBSRC EPSRC Synthet Biol Res Ctr SBRC, Nottingham, England |
推荐引用方式 GB/T 7714 | Ngoc-Phuong-Thao Nguyen,Raynaud, Celine,Meynial-Salles, Isabelle,et al. Reviving the Weizmann process for commercial n-butanol production[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Ngoc-Phuong-Thao Nguyen,Raynaud, Celine,Meynial-Salles, Isabelle,&Soucaille, Philippe.(2019).Reviving the Weizmann process for commercial n-butanol production.NATURE COMMUNICATIONS,9. |
MLA | Ngoc-Phuong-Thao Nguyen,et al."Reviving the Weizmann process for commercial n-butanol production".NATURE COMMUNICATIONS 9(2019). |
条目包含的文件 | 条目无相关文件。 |
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