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DOI | 10.1038/s41467-019-08592-5 |
Specific hippocampal representations are linked to generalized cortical representations in memory | |
Yu, Jai Y.1,2; Liu, Daniel F.1,2,3; Loback, Adrianna4; Grossrubatscher, Irene3; Frank, Loren M.1,2,5,6 | |
2019-02-14 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Memories link information about specific experiences to more general knowledge that is abstracted from and contextualizes those experiences. Hippocampal-cortical activity patterns representing features of past experience are reinstated during awake memory reactivation events, but whether representations of both specific and general features of experience are simultaneously reinstated remains unknown. We examined hippocampal and prefrontal cortical firing patterns during memory reactivation in rats performing a well-learned foraging task with multiple spatial paths. We found that specific hippocampal place representations are preferentially reactivated with the subset of prefrontal cortical task representations that generalize across different paths. Our results suggest that hippocampal-cortical networks maintain links between stored representations for specific and general features of experience, which could support abstraction and task guidance in mammals. |
领域 | 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000434379800006 |
WOS关键词 | MEDIAL PREFRONTAL CORTEX ; COMPLEMENTARY LEARNING-SYSTEMS ; SHARP-WAVE RIPPLES ; WORKING-MEMORY ; SPATIAL MEMORY ; TRANSITIVE INFERENCE ; SEMANTIC MEMORY ; PLACE CELLS ; RAT ; SLEEP |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204219 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Calif San Francisco, UCSF Ctr Integrat Neurosci, San Francisco, CA 94143 USA; 2.Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA; 3.Univ Calif Berkeley, Berkeley, CA 94720 USA; 4.Princeton Univ, Princeton, NJ 08544 USA; 5.Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA; 6.Univ Calif San Francisco, Kavli Inst Fundamental Neurosci, San Francisco, CA 94143 USA |
推荐引用方式 GB/T 7714 | Yu, Jai Y.,Liu, Daniel F.,Loback, Adrianna,et al. Specific hippocampal representations are linked to generalized cortical representations in memory[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Yu, Jai Y.,Liu, Daniel F.,Loback, Adrianna,Grossrubatscher, Irene,&Frank, Loren M..(2019).Specific hippocampal representations are linked to generalized cortical representations in memory.NATURE COMMUNICATIONS,9. |
MLA | Yu, Jai Y.,et al."Specific hippocampal representations are linked to generalized cortical representations in memory".NATURE COMMUNICATIONS 9(2019). |
条目包含的文件 | 条目无相关文件。 |
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