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DOI | 10.1038/s41467-019-08758-1 |
Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPAR gamma | |
Mao, Hua1,2; Lockyer, Pamela3; Li, Luge1,2; Ballantyne, Christie M.4; Patterson, Cam5; Xie, Liang1,2; Pi, Xinchun1,2 | |
2019-02-18 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Low-density lipoprotein receptor-related protein 1 (LRP1) regulates lipid and glucose metabolism in liver and adipose tissue. It is also involved in central nervous system regulation of food intake and leptin signalling. Here we demonstrate that endothelial Lrp1 regulates systemic energy homeostasis. Mice with endothelial-specific Lrp1 deletion display improved glucose sensitivity and lipid profiles combined with increased oxygen consumption during high-fat-diet-induced obesity. We show that the intracellular domain of Lrp1 interacts with the nuclear receptor Ppar gamma, a central regulator of lipid and glucose metabolism, acting as its transcriptional co-activator in endothelial cells. Therefore, Lrp1 not only acts as an endocytic receptor but also directly participates in gene transcription. Our findings indicate an underappreciated functional role of endothelium in maintaining systemic energy homeostasis. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000398926200001 |
WOS关键词 | RECEPTOR-RELATED PROTEIN ; INSULIN-RESISTANCE ; LIGAND-BINDING ; MICE ; CELLS ; ATHEROSCLEROSIS ; ANGIOGENESIS ; HOMEOSTASIS ; EXPRESSION ; CLEARANCE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204227 |
专题 | 资源环境科学 |
作者单位 | 1.Baylor Coll Med, Cardiovasc Res Inst, Houston, TX 77030 USA; 2.Baylor Coll Med, Dept Med, Houston, TX 77030 USA; 3.Univ North Carolina Chapel Hill, Dept Pathol & Lab Med, Chapel Hill, NC 27599 USA; 4.Baylor Coll Med, Ctr Cardiovasc Dis Prevent, Methodist DeBakey Heart & Vasc Ctr, Sect Cardiovasc Res,Dept Med, Houston, TX 77030 USA; 5.New York Presbyterian Hosp, New York, NY 10065 USA |
推荐引用方式 GB/T 7714 | Mao, Hua,Lockyer, Pamela,Li, Luge,et al. Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPAR gamma[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Mao, Hua.,Lockyer, Pamela.,Li, Luge.,Ballantyne, Christie M..,Patterson, Cam.,...&Pi, Xinchun.(2019).Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPAR gamma.NATURE COMMUNICATIONS,8. |
MLA | Mao, Hua,et al."Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPAR gamma".NATURE COMMUNICATIONS 8(2019). |
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