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DOI | 10.1038/s41467-019-08837-3 |
PNLDC1 is essential for piRNA 3 ' end trimming and transposon silencing during spermatogenesis in mice | |
Ding, Deqiang1; Liu, Jiali1,2; Dong, Kunzhe3; Midic, Uros1; Hess, Rex A.4; Xie, Huirong5; Demireva, Elena Y.5; Chen, Chen1,6,7 | |
2019-02-22 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Peoples R China |
英文摘要 | Piwi-interacting RNAs are small regulatory RNAs with key roles in transposon silencing and regulation of gametogenesis. The production of mature piwi-interacting RNAs requires a critical step of trimming piwi-interacting RNA intermediates to achieve optimally sized piwi-interacting RNAs. The poly(A)-specific ribonuclease family deadenylase PNLDC1 is implicated in piwi-interacting RNA trimming in silkworms. The physiological function of PNLDC1 in mammals remains unknown. Using Pnldc1-deficient mice, here we show that PNLDC1 is required for piwi-interacting RNA biogenesis, transposon silencing, and spermatogenesis. Pnldc1 mutation in mice inhibits piwi-interacting RNA trimming and causes accumulation of untrimmed piwi-interacting RNA intermediates with 3' end extension, leading to severe reduction of mature piwi-interacting RNAs in the testis. Pnldc1 mutant mice exhibit disrupted LINE1 retrotransposon silencing and defect in spermiogenesis. Together, these results define PNLDC1 as a mammalian piwi-interacting RNA biogenesis factor that protects the germline genome and ensures normal sperm production in mice. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000412603600004 |
WOS关键词 | SMALL RNAS ; PIWI PROTEINS ; MOUSE TESTES ; NUAGE FORMATION ; GERMLINE ; BIOGENESIS ; GENOME ; PATHWAY ; CELLS ; MECHANISMS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204238 |
专题 | 资源环境科学 |
作者单位 | 1.Michigan State Univ, Dept Anim Sci, E Lansing, MI 48824 USA; 2.China Agr Univ, Coll Biol Sci, State Key Lab Agrobiotechnol, Beijing 100193, Peoples R China; 3.ARS, USDA, Avian Dis & Oncol Lab, E Lansing, MI 48823 USA; 4.Univ Illinois, Dept Comparat Biosci, Urbana, IL 61801 USA; 5.Michigan State Univ, Transgen & Genome Editing Facil, E Lansing, MI 48824 USA; 6.Michigan State Univ, Reprod & Dev Sci Program, E Lansing, MI 48824 USA; 7.Michigan State Univ, Dept Obstet Gynecol & Reprod Biol, Grand Rapids, MI 49503 USA |
推荐引用方式 GB/T 7714 | Ding, Deqiang,Liu, Jiali,Dong, Kunzhe,et al. PNLDC1 is essential for piRNA 3 ' end trimming and transposon silencing during spermatogenesis in mice[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Ding, Deqiang.,Liu, Jiali.,Dong, Kunzhe.,Midic, Uros.,Hess, Rex A..,...&Chen, Chen.(2019).PNLDC1 is essential for piRNA 3 ' end trimming and transposon silencing during spermatogenesis in mice.NATURE COMMUNICATIONS,8. |
MLA | Ding, Deqiang,et al."PNLDC1 is essential for piRNA 3 ' end trimming and transposon silencing during spermatogenesis in mice".NATURE COMMUNICATIONS 8(2019). |
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