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DOI | 10.1038/s41467-019-08984-7 |
Systemic control of immune cell development by integrated carbon dioxide and hypoxia chemosensation in Drosophila | |
Cho, Bumsik1; Spratford, Carrie M.2; Yoon, Sunggyu1; Cha, Nuri1; Banerjee, Utpal2,3,4; Shim, Jiwon1,5,6 | |
2019-03-26 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | South Korea; USA |
英文摘要 | Drosophila hemocytes are akin to mammalian myeloid blood cells that function in stress and innate immune-related responses. A multi-potent progenitor population responds to local signals and to systemic stress by expanding the number of functional blood cells. Here we show mechanisms that demonstrate an integration of environmental carbon dioxide (CO2) and oxygen (O-2) inputs that initiate a cascade of signaling events, involving multiple organs, as a stress response when the levels of these two important respiratory gases fall below a threshold. The CO2 and hypoxia-sensing neurons interact at the synaptic level in the brain sending a systemic signal via the fat body to modulate differentiation of a specific class of immune cells. Our findings establish a link between environmental gas sensation and myeloid cell development in Drosophila. A similar relationship exists in humans, but the underlying mechanisms remain to be established. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000438197600005 |
WOS关键词 | SOLUBLE GUANYLYL CYCLASES ; BLOOD-CELLS ; PROGENITOR MAINTENANCE ; RESPIRATORY CONTROL ; AVOIDANCE-BEHAVIOR ; INNATE IMMUNITY ; CAROTID-BODY ; HEMATOPOIESIS ; NEURONS ; OXYGEN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204287 |
专题 | 资源环境科学 |
作者单位 | 1.Hanyang Univ, Dept Life Sci, Coll Nat Sci, Seoul 04763, South Korea; 2.Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA; 3.Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA; 4.Univ Calif Los Angeles, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Los Angeles, CA 90095 USA; 5.Hanyang Univ, Res Inst Nat Sci, Seoul 04763, South Korea; 6.Hanyang Univ, Res Inst Convergence Basic Sci, Seoul 04763, South Korea |
推荐引用方式 GB/T 7714 | Cho, Bumsik,Spratford, Carrie M.,Yoon, Sunggyu,et al. Systemic control of immune cell development by integrated carbon dioxide and hypoxia chemosensation in Drosophila[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Cho, Bumsik,Spratford, Carrie M.,Yoon, Sunggyu,Cha, Nuri,Banerjee, Utpal,&Shim, Jiwon.(2019).Systemic control of immune cell development by integrated carbon dioxide and hypoxia chemosensation in Drosophila.NATURE COMMUNICATIONS,9. |
MLA | Cho, Bumsik,et al."Systemic control of immune cell development by integrated carbon dioxide and hypoxia chemosensation in Drosophila".NATURE COMMUNICATIONS 9(2019). |
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