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DOI | 10.1038/s41467-019-09080-6 |
Host-inherent variability influences the transcriptional response of Staphylococcus aureus during in vivo infection | |
Thaenert, Robert1; Goldmann, Oliver1; Beineke, Andreas2; Medina, Eva1 | |
2019-04-02 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany |
英文摘要 | The rise of antibiotic resistance calls for alternative strategies to treat bacterial infections. One attractive strategy is to directly target bacterial virulence factors with anti-virulence drugs. The expression of virulence traits by pathogens is, however, not constitutive but rather induced by the level of stress encountered within the host. Here we use dual RNA sequencing (RNA-seq) to show that intrinsic variability in the level of host resistance greatly affects the pathogen's transcriptome in vivo. Through analysis of the transcriptional profiles of host and pathogen during Staphylococcus aureus infection of two mouse strains, shown to be susceptible (A/J) or resistant (C57BL/6) to the pathogen, we demonstrate that the expression of virulence factors is dependent on the encountered host resistance. We furthermore provide evidence that this dependence strongly influences the efficacy of anti-virulence strategies, highlighting a potential limitation for the implementation of these strategies. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000393228500001 |
WOS关键词 | GENE REGULATOR AGR ; DUAL RNA-SEQ ; EXTRACELLULAR PROTEASES ; PATHOGEN INTERACTIONS ; VIRULENCE ; EXPRESSION ; IDENTIFICATION ; AUREOLYSIN ; RESISTANCE ; STRATEGIES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204296 |
专题 | 资源环境科学 |
作者单位 | 1.Helmholtz Ctr Infect Res, Infect Immunol Res Grp, Inhoffenstr 7, D-38124 Braunschweig, Germany; 2.Univ Vet Med Hannover, Inst Pathol, Bunteweg 17, D-30559 Hannover, Germany |
推荐引用方式 GB/T 7714 | Thaenert, Robert,Goldmann, Oliver,Beineke, Andreas,et al. Host-inherent variability influences the transcriptional response of Staphylococcus aureus during in vivo infection[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Thaenert, Robert,Goldmann, Oliver,Beineke, Andreas,&Medina, Eva.(2019).Host-inherent variability influences the transcriptional response of Staphylococcus aureus during in vivo infection.NATURE COMMUNICATIONS,8. |
MLA | Thaenert, Robert,et al."Host-inherent variability influences the transcriptional response of Staphylococcus aureus during in vivo infection".NATURE COMMUNICATIONS 8(2019). |
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