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DOI | 10.1038/s41467-019-09580-5 |
Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii | |
Frenal, Karine1; Jacot, Damien1; Hammoudi, Pierre-Mehdi1; Arnault, Graindorge W.1,2; Maco, Bohumil1; Soldati-Favre, Dominique1 | |
2019-04-08 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland; France |
英文摘要 | The obligate intracellular parasite Toxoplasma gondii possesses a repertoire of 11 myosins. Three class XIV motors participate in motility, invasion and egress, whereas the class XXII myosin F is implicated in organelle positioning and inheritance of the apicoplast. Here we provide evidence that TgUNC acts as a chaperone dedicated to the folding, assembly and function of all Toxoplasma myosins. The conditional ablation of TgUNC recapitulates the phenome of the known myosins and uncovers two functions in parasite basal complex constriction and synchronized division within the parasitophorous vacuole. We identify myosin J and centrin 2 as essential for the constriction. We demonstrate the existence of an intravacuolar cell-cell communication ensuring synchronized division, a process dependent on myosin I. This connectivity contributes to the delayed death phenotype resulting from loss of the apicoplast. Cell-cell communication is lost in activated macrophages and during bradyzoite differentiation resulting in asynchronized, slow division in the cysts. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000402869200001 |
WOS关键词 | APICOMPLEXAN PARASITES ; CAENORHABDITIS-ELEGANS ; CONOID EXTRUSION ; ACTIN-FILAMENTS ; PLASMA-MEMBRANE ; PROTEIN-KINASE ; UCS DOMAIN ; IN-VITRO ; INVASION ; MOTOR |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204305 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Geneva, Dept Microbiol & Mol Med, CMU, 1 Rue Michel Servet, CH-1206 Geneva, Switzerland; 2.Fac Sci Pharmaceut & Biol, Lab Biol Cellulaire & Mol, 15 Ave Charles Flahault, F-340935 Montpellier, France |
推荐引用方式 GB/T 7714 | Frenal, Karine,Jacot, Damien,Hammoudi, Pierre-Mehdi,et al. Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Frenal, Karine,Jacot, Damien,Hammoudi, Pierre-Mehdi,Arnault, Graindorge W.,Maco, Bohumil,&Soldati-Favre, Dominique.(2019).Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii.NATURE COMMUNICATIONS,8. |
MLA | Frenal, Karine,et al."Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii".NATURE COMMUNICATIONS 8(2019). |
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