GSTDTAP  > 资源环境科学
DOI10.1038/s41467-019-09630-y
Sortilin limits EGFR signaling by promoting its internalization in lung cancer
Al-Akhrass, Hussein1,2; Naves, Thomas1,2; Vincent, Francois1,2,3; Magnaudeix, Amandine1,2; Durand, Karine1,2,4; Bertin, Francois5; Melloni, Boris3; Jauberteau, Marie-Odile1,2,6; Lalloue, Fabrice1,2
2019-04-09
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
出版年2017
卷号8
文章类型Article
语种英语
国家France
英文摘要

Tyrosine kinase receptors such as the epidermal growth factor receptor (EGFR) transduce information from the microenvironment into the cell and activate homeostatic signaling pathways. Internalization and degradation of EGFR after ligand binding limits the intensity of proliferative signaling, thereby helping to maintain cell integrity. In cancer cells, deregulation of EGFR trafficking has a variety of effects on tumor progression. Here we report that sortilin is a key regulator of EGFR internalization. Loss of sortilin in tumor cells promoted cell proliferation by sustaining EGFR signaling at the cell surface, ultimately accelerating tumor growth. In lung cancer patients, sortilin expression decreased with increased pathologic grade, and expression of sortilin was strongly correlated with survival, especially in patients with high EGFR expression. Sortilin is therefore a regulator of EGFR intracellular trafficking that promotes receptor internalization and limits signaling, which in turn impacts tumor growth.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000413894100004
WOS关键词EPIDERMAL-GROWTH-FACTOR ; PROTEIN-KINASE CASCADE ; FACTOR RECEPTOR ; EXPRESSION ; TRAFFICKING ; CARCINOMA ; ADENOCARCINOMA ; GOLGI ; PHOSPHORYLATION ; LOCALIZATION
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/204310
专题资源环境科学
作者单位1.Univ Limoges, Fac Med, Homeostasie Cellulaire & Pathol EA3842, 2 Rue Dr Raymond Marcland, F-87025 Limoges, France;
2.Univ Limoges, Fac Med, Chaire Pneumol Expt, 2 Rue Dr Raymond Marcland, F-87025 Limoges, France;
3.CHU Limoges, Serv Pathol Resp, F-87042 Limoges, France;
4.CHU Limoges, Serv Anat Pathol, F-87042 Limoges, France;
5.CHU Limoges, Serv Chirurg Thorac & Cardiovasc, F-87042 Limoges, France;
6.CHU Limoges, Serv Immunol, F-87042 Limoges, France
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GB/T 7714
Al-Akhrass, Hussein,Naves, Thomas,Vincent, Francois,et al. Sortilin limits EGFR signaling by promoting its internalization in lung cancer[J]. NATURE COMMUNICATIONS,2019,8.
APA Al-Akhrass, Hussein.,Naves, Thomas.,Vincent, Francois.,Magnaudeix, Amandine.,Durand, Karine.,...&Lalloue, Fabrice.(2019).Sortilin limits EGFR signaling by promoting its internalization in lung cancer.NATURE COMMUNICATIONS,8.
MLA Al-Akhrass, Hussein,et al."Sortilin limits EGFR signaling by promoting its internalization in lung cancer".NATURE COMMUNICATIONS 8(2019).
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