Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-019-09630-y |
Sortilin limits EGFR signaling by promoting its internalization in lung cancer | |
Al-Akhrass, Hussein1,2; Naves, Thomas1,2; Vincent, Francois1,2,3; Magnaudeix, Amandine1,2; Durand, Karine1,2,4; Bertin, Francois5; Melloni, Boris3; Jauberteau, Marie-Odile1,2,6; Lalloue, Fabrice1,2 | |
2019-04-09 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | France |
英文摘要 | Tyrosine kinase receptors such as the epidermal growth factor receptor (EGFR) transduce information from the microenvironment into the cell and activate homeostatic signaling pathways. Internalization and degradation of EGFR after ligand binding limits the intensity of proliferative signaling, thereby helping to maintain cell integrity. In cancer cells, deregulation of EGFR trafficking has a variety of effects on tumor progression. Here we report that sortilin is a key regulator of EGFR internalization. Loss of sortilin in tumor cells promoted cell proliferation by sustaining EGFR signaling at the cell surface, ultimately accelerating tumor growth. In lung cancer patients, sortilin expression decreased with increased pathologic grade, and expression of sortilin was strongly correlated with survival, especially in patients with high EGFR expression. Sortilin is therefore a regulator of EGFR intracellular trafficking that promotes receptor internalization and limits signaling, which in turn impacts tumor growth. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413894100004 |
WOS关键词 | EPIDERMAL-GROWTH-FACTOR ; PROTEIN-KINASE CASCADE ; FACTOR RECEPTOR ; EXPRESSION ; TRAFFICKING ; CARCINOMA ; ADENOCARCINOMA ; GOLGI ; PHOSPHORYLATION ; LOCALIZATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204310 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Limoges, Fac Med, Homeostasie Cellulaire & Pathol EA3842, 2 Rue Dr Raymond Marcland, F-87025 Limoges, France; 2.Univ Limoges, Fac Med, Chaire Pneumol Expt, 2 Rue Dr Raymond Marcland, F-87025 Limoges, France; 3.CHU Limoges, Serv Pathol Resp, F-87042 Limoges, France; 4.CHU Limoges, Serv Anat Pathol, F-87042 Limoges, France; 5.CHU Limoges, Serv Chirurg Thorac & Cardiovasc, F-87042 Limoges, France; 6.CHU Limoges, Serv Immunol, F-87042 Limoges, France |
推荐引用方式 GB/T 7714 | Al-Akhrass, Hussein,Naves, Thomas,Vincent, Francois,et al. Sortilin limits EGFR signaling by promoting its internalization in lung cancer[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Al-Akhrass, Hussein.,Naves, Thomas.,Vincent, Francois.,Magnaudeix, Amandine.,Durand, Karine.,...&Lalloue, Fabrice.(2019).Sortilin limits EGFR signaling by promoting its internalization in lung cancer.NATURE COMMUNICATIONS,8. |
MLA | Al-Akhrass, Hussein,et al."Sortilin limits EGFR signaling by promoting its internalization in lung cancer".NATURE COMMUNICATIONS 8(2019). |
条目包含的文件 | 条目无相关文件。 |
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