Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-019-09282-y |
Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons | |
Lee, Bora1; Kim, Janghyun2; An, Taekyeong3; Kim, Sangsoo3; Patel, Esha M.4; Raber, Jacob4,5,6,7; Lee, Soo-Kyung2,8; Lee, Seunghee9,10; Lee, Jae W.2 | |
2019-04-18 | |
发表期刊 | NATURE COMMUNICATIONS
![]() |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | South Korea; USA |
英文摘要 | Despite critical roles of the hypothalamic arcuate neurons in controlling the growth and energy homeostasis, the gene regulatory network directing their development remains unclear. Here we report that the transcription factors Dlx1/2 and Otp coordinate the balanced generation of the two functionally related neurons in the hypothalamic arcuate nucleus, GHRH-neurons promoting the growth and AgRP-neurons controlling the feeding and energy expenditure. Dlx1/2-deficient mice show a loss-of-GHRH-neurons and an increase of AgRP-neurons, and consistently develop dwarfism and consume less energy. These results indicate that Dlx1/2 are crucial for specifying the GHRH-neuronal identity and, simultaneously, for suppressing AgRP-neuronal fate. We further show that Otp is required for the generation of AgRP-neurons and that Dlx1/2 repress the expression of Otp by directly binding the Otp gene. Together, our study demonstrates that the identity of GHRH- and AgRP-neurons is synchronously specified and segregated by the Dlx1/2-Otp gene regulatory axis. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000432792100002 |
WOS关键词 | ARCUATE NUCLEUS ; TRANSCRIPTION FACTORS ; DOPAMINERGIC-NEURONS ; HOMEOBOX FACTOR ; MOUSE ; EXPRESSION ; GROWTH ; MICE ; GENE ; DIFFERENTIATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204327 |
专题 | 资源环境科学 |
作者单位 | 1.KIST, Ctr Neurosci, Seoul 02792, South Korea; 2.Oregon Hlth & Sci Univ, Dept Pediat, Pape Family Pediat Res Ctr, Neurosci Sect, Portland, OR 97239 USA; 3.Soongsil Univ, Dept Bioinformat & Life Sci, Seoul 06978, South Korea; 4.Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA; 5.Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Dept Neurol, Portland, OR 97239 USA; 6.Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Dept Radiat Med, Portland, OR 97239 USA; 7.Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Div Neurosci, Portland, OR 97239 USA; 8.Oregon Hlth & Sci Univ, Vollum Inst, Portland, OR 97239 USA; 9.Seoul Natl Univ, Coll Pharm, Seoul 08826, South Korea; 10.Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 08826, South Korea |
推荐引用方式 GB/T 7714 | Lee, Bora,Kim, Janghyun,An, Taekyeong,et al. Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Lee, Bora.,Kim, Janghyun.,An, Taekyeong.,Kim, Sangsoo.,Patel, Esha M..,...&Lee, Jae W..(2019).Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons.NATURE COMMUNICATIONS,9. |
MLA | Lee, Bora,et al."Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons".NATURE COMMUNICATIONS 9(2019). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论