Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-019-10032-3 |
A spatial gradient of bacterial diversity in the human oral cavity shaped by salivary flow | |
Proctor, Diana M.1,2,3; Fukuyama, Julia A.4; Loomer, Peter M.3,5; Armitage, Gary C.3; Lee, Stacey A.3; Davis, Nicole M.1; Ryder, Mark I.3; Holmes, Susan P.6; Relman, David A.1,2,7 | |
2019-05-03 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Spatial and temporal patterns in microbial communities provide insights into the forces that shape them, their functions and roles in health and disease. Here, we used spatial and ecological statistics to analyze the role that saliva plays in structuring bacterial communities of the human mouth using > 9000 dental and mucosal samples. We show that regardless of tissue type (teeth, alveolar mucosa, keratinized gingiva, or buccal mucosa), surface-associated bacterial communities vary along an ecological gradient from the front to the back of the mouth, and that on exposed tooth surfaces, the gradient is pronounced on lingual compared to buccal surfaces. Furthermore, our data suggest that this gradient is attenuated in individuals with low salivary flow due to Sjogren's syndrome. Taken together, our findings imply that salivary flow influences the spatial organization of microbial communities and that biogeographical patterns may be useful for understanding host physiological processes and for predicting disease. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000424989600002 |
WOS关键词 | LANDSCAPE ECOLOGY ; SJOGRENS-SYNDROME ; DENTAL-CARIES ; PLAQUE PH ; MICROBIOTA ; MICROORGANISMS ; BIOGEOGRAPHY ; TEMPERATURE ; XEROSTOMIA ; MICROFLORA |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204355 |
专题 | 资源环境科学 |
作者单位 | 1.Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA; 2.Vet Affairs Palo Alto Hlth Care Syst, Infect Dis Sect, Palo Alto, CA 94304 USA; 3.Univ Calif San Francisco, San Francisco Sch Dent, Div Periodontol, San Francisco, CA 94143 USA; 4.Fred Hutchinson Canc Res Inst, Dept Computat Biol, Seattle, WA 98109 USA; 5.NYU, Coll Dent, Ashmans Dept Periodontol & Implant Dent, New York, NY 10010 USA; 6.Stanford Univ, Dept Stat, Stanford, CA 94305 USA; 7.Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Proctor, Diana M.,Fukuyama, Julia A.,Loomer, Peter M.,et al. A spatial gradient of bacterial diversity in the human oral cavity shaped by salivary flow[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Proctor, Diana M..,Fukuyama, Julia A..,Loomer, Peter M..,Armitage, Gary C..,Lee, Stacey A..,...&Relman, David A..(2019).A spatial gradient of bacterial diversity in the human oral cavity shaped by salivary flow.NATURE COMMUNICATIONS,9. |
MLA | Proctor, Diana M.,et al."A spatial gradient of bacterial diversity in the human oral cavity shaped by salivary flow".NATURE COMMUNICATIONS 9(2019). |
条目包含的文件 | 条目无相关文件。 |
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