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DOI | 10.1038/s41467-019-10191-3 |
Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map | |
Albeanu, Dinu F.1; Provost, Allison C.2,3; Agarwal, Prateek2,3; Soucy, Edward R.2,3; Zak, Joseph D.2,3; Murthy, Venkatesh N.2,3 | |
2019-05-16 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Inputs from olfactory sensory neuron (OSN) axons expressing the same type of odorant receptor (OR) converge in the glomerulus of the main olfactory bulb. A key marker of mature OSNs is olfactory marker protein (OMP), whose deletion has been associated with deficits in OSN signal transduction and odor discrimination. Here, we investigate glomerular odor responses and anatomical architecture in mice in which one or both alleles of OMP are replaced by the fluorescent synaptic activity reporter, synaptopHluorin. Functionally heterogeneous glomeruli, that is, ones with microdomains with distinct odor responses, are rare in OMP+/- mice, but occur frequently in OMP-/- mice. Genetic targeting of single ORs reveals that these microdomains arise from co-innervation of individual glomeruli by OSNs expressing different ORs. This glomerular mistargeting is locally restricted to a few glomerular diameters. Our studies document functional heterogeneity in sensory input within individual glomeruli and uncover its anatomical correlate, revealing an unexpected role for OMP in the formation and refinement of the glomerular map. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000451621700021 |
WOS关键词 | ODORANT RECEPTOR GENE ; SENSORY NEURONS ; MOUSE ; ORGANIZATION ; BULB ; EXPRESSION ; INPUT ; CONVERGENCE ; PROJECTIONS ; DELETION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204369 |
专题 | 资源环境科学 |
作者单位 | 1.Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA; 2.Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA; 3.Harvard Univ, Ctr Brain Sci, Cambridge, MA 02138 USA |
推荐引用方式 GB/T 7714 | Albeanu, Dinu F.,Provost, Allison C.,Agarwal, Prateek,et al. Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Albeanu, Dinu F.,Provost, Allison C.,Agarwal, Prateek,Soucy, Edward R.,Zak, Joseph D.,&Murthy, Venkatesh N..(2019).Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map.NATURE COMMUNICATIONS,9. |
MLA | Albeanu, Dinu F.,et al."Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map".NATURE COMMUNICATIONS 9(2019). |
条目包含的文件 | 条目无相关文件。 |
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