Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression

doi:10.1038/s41467-019-11340-4

GSTDTAP > 资源环境科学

DOI	10.1038/s41467-019-11340-4
	Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression
	Contrepois, Kevin 1,2; Coudereau, Clement 1; Benayoun, Berenice A.2,3; Schuler, Nadine 4; Roux, Pierre-Francois 5; Bischof, Oliver 5; Courbeyrette, Regis 1; Carvalho, Cyril 1; Thuret, Jean-Yves 1; Ma, Zhihai 2; Derbois, Celine 6; Nevers, Marie-Claire 7; Volland, Herve 7; Redon, Christophe E.8; Bonner, William M.8; Deleuze, Jean-Francois 6; Wiel, Clotilde 9; Bernard, David 9; Snyder, Michael P.2; Ruebe, Claudia E.4; Olaso, Robert 6; Fenaille, Francois 10; Mann, Carl 1
	2019-07-26
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
出版年	2017
卷号	8
文章类型	Article
语种	英语
国家	France; USA; Germany
英文摘要	The senescence of mammalian cells is characterized by a proliferative arrest in response to stress and the expression of an inflammatory phenotype. Here we show that histone H2A.J, a poorly studied H2A variant found only in mammals, accumulates in human fibroblasts in senescence with persistent DNA damage. H2A.J also accumulates in mice with aging in a tissue-specific manner and in human skin. Knock-down of H2A.J inhibits the expression of inflammatory genes that contribute to the senescent-associated secretory phenotype (SASP), and over expression of H2A.J increases the expression of some of these genes in proliferating cells. H2A.J accumulation may thus promote the signalling of senescent cells to the immune system, and it may contribute to chronic inflammation and the development of aging-associated diseases.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000400886800001
WOS关键词	CELLULAR SENESCENCE ; CANCER ; MICE ; SIDE
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/204465
专题	资源环境科学
作者单位	1.Univ Paris Saclay, Univ Paris Sud, I2BC, CEA,CNRS, F-91198 Gif Sur Yvette, France; 2.Stanford Univ, Dept Genet, Stanford, CA 94305 USA; 3.Stanford Univ, Paul F Glenn Labs Biol Aging, Stanford, CA 94305 USA; 4.Saarland Univ, Dept Radiat Oncol, D-66421 Homburg, Saar, Germany; 5.Inst Pasteur, Lab Nucl Org & Oncogenesis, Dept Cell Biol & Infect, INSERM,U933, F-75015 Paris, France; 6.CEA, CNG, F-91057 Evry, France; 7.Univ Paris Saclay, INRA, CEA, SPI, F-91191 Gif Sur Yvette, France; 8.NCI, Mol Pharmacol Lab, CCR, NIH, Bethesda, MD 20892 USA; 9.Univ Lyon, Ctr Leon Berard, Ctr Rech Cancerol Lyon, CNRS,UMR5286,Inserm,U1052, F-69008 Lyon, France; 10.Univ Paris Saclay, Lab Etud Metab Medicaments, Serv Pharmacol & Immunoanal, MetaboHUB Paris,CEA,IBITECS,UMR 0496, F-91191 Gif Sur Yvette, France
推荐引用方式 GB/T 7714	Contrepois, Kevin,Coudereau, Clement,Benayoun, Berenice A.,et al. Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression[J]. NATURE COMMUNICATIONS,2019,8.
APA	Contrepois, Kevin.,Coudereau, Clement.,Benayoun, Berenice A..,Schuler, Nadine.,Roux, Pierre-Francois.,...&Mann, Carl.(2019).Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression.NATURE COMMUNICATIONS,8.
MLA	Contrepois, Kevin,et al."Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression".NATURE COMMUNICATIONS 8(2019).