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DOI | 10.1038/s41467-019-11453-w |
GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21 | |
Wiemels, Joseph L.1,2,3,4; Walsh, Kyle M.1,2; de Smith, Adam J.1; Metayer, Catherine5; Gonseth, Semira1,4; Hansen, Helen M.2; Francis, Stephen S.1,6; Ojha, Juhi1; Smirnov, Ivan2; Barcellos, Lisa5; Xiao, Xiaorong5; Morimoto, Libby5; McKean-Cowdin, Roberta4; Wang, Rong7; Yu, Herbert8; Hoh, Josephine7; Dewan, Andrew T.7; Ma, Xiaomei7 | |
2019-07-30 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Childhood acute lymphoblastic leukemia (ALL) (age 0-14 years) is 20% more common in Latino Americans than non-Latino whites. We conduct a genome-wide association study in a large sample of 3263 Californian children with ALL (including 1949 of Latino heritage) and 3506 controls matched on month and year of birth, sex, and ethnicity, and an additional 12,471 controls from the Kaiser Resource for Genetic Epidemiology Research on Aging Cohort. Replication of the strongest genetic associations is performed in two independent datasets from the Children's Oncology Group and the California Childhood Leukemia Study. Here we identify new risk loci on 17q12 near IKZF3/ZPBP2/GSDMB/ORMDL3, a locus encompassing a transcription factor important for lymphocyte development (IKZF3), and at an 8q24 region known for structural contacts with the MYC oncogene. These new risk loci may impact gene expression via local (four 17q12 genes) or long-range (8q24) interactions, affecting function of well-characterized hematopoietic and growth-regulation pathways. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000422745800021 |
WOS关键词 | GENOME-WIDE ASSOCIATION ; SUSCEPTIBILITY LOCI ; FUNCTIONAL VARIATION ; RISK LOCI ; VARIANTS ; CHILDREN ; METAANALYSES ; IMPUTATION ; CDKN2A ; RELAPSE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204469 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Calif San Francisco, Dept Epidemiol & Biostat, 1450 3rd St, San Francisco, CA 94158 USA; 2.Univ Calif San Francisco, Dept Neurol Surg, 1450 3rd St, San Francisco, CA 94158 USA; 3.Univ Calif San Francisco, Inst Human Genet, 1450 3rd St, San Francisco, CA 94158 USA; 4.Univ Southern Calif, Dept Preventat Med, SSB 318D 2001 N Soto St, Los Angeles, CA 90033 USA; 5.Univ Calif Berkeley, Sch Publ Hlth, 1950 Univ Ave,Suite 460, Berkeley, CA 94720 USA; 6.Univ Nevada Reno, Sch Community Hlth Sci, Dept Epidemiol, 1664 N Virginia St, Reno, NV 89557 USA; 7.Yale Univ, Sch Publ Hlth, Dept Chron Dis Epidemiol, 60 Coll St, New Haven, CT 06520 USA; 8.Univ Hawaii, Canc Ctr, 701 Ilalo St, Honolulu, HI 96813 USA |
推荐引用方式 GB/T 7714 | Wiemels, Joseph L.,Walsh, Kyle M.,de Smith, Adam J.,et al. GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Wiemels, Joseph L..,Walsh, Kyle M..,de Smith, Adam J..,Metayer, Catherine.,Gonseth, Semira.,...&Ma, Xiaomei.(2019).GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21.NATURE COMMUNICATIONS,9. |
MLA | Wiemels, Joseph L.,et al."GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21".NATURE COMMUNICATIONS 9(2019). |
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