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DOI | 10.1038/s41467-019-11064-5 |
A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage | |
Shan, Chao1; Muruato, Antonio E.2; Jagger, Brett W.3; Richner, Justin3; Nunes, Bruno T. D.1,4; Medeiros, Daniele B. A.1,4; Xie, Xuping1; Nunes, Jannyce G. C.1,4; Morabito, Kaitlyn M.5; Kong, Wing-Pui5; Pierson, Theodore C.6; Barrett, Alan D.7,8,9,10; Weaver, Scott C.2,10,11,12; Rossi, Shannan L.7,8,9; Vasconcelos, Pedro F. C.4,13; Graham, Barney S.6; Diamond, Michael S.3,14,15,16; Shi, Pei-Yong1,10,11,13,17 | |
2019-09-02 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Brazil |
英文摘要 | Zika virus infection during pregnancy can cause congenital abnormities or fetal demise. The persistence of Zika virus in the male reproductive system poses a risk of sexual transmission. Here we demonstrate that live-attenuated Zika virus vaccine candidates containing deletions in the 3' untranslated region of the Zika virus genome (ZIKV-3'UTR-LAV) prevent viral transmission during pregnancy and testis damage in mice, as well as infection of nonhuman primates. After a single-dose vaccination, pregnant mice challenged with Zika virus at embryonic day 6 and evaluated at embryonic day 13 show markedly diminished levels of viral RNA in maternal, placental, and fetal tissues. Vaccinated male mice challenged with Zika virus were protected against testis infection, injury, and oligospermia. A single immunization of rhesus macaques elicited a rapid and robust antibody response, conferring complete protection upon challenge. Furthermore, the ZIKV-3'UTR-LAV vaccine candidates have a desirable safety profile. These results suggest that further development of ZIKV-3'UTR-LAV is warranted for humans. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000411526700021 |
WOS关键词 | SEXUAL TRANSMISSION ; PROTECTION ; INFECTION ; MICE ; ANTIBODIES ; IMMUNITY ; DISEASE ; BRAZIL |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204517 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Texas Med Branch, Dept Biochem & Mol Biol, Galveston, TX 77555 USA; 2.Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA; 3.Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA; 4.Minist Hlth, Evandro Chagas Inst, Dept Arbovirol & Hemorrhag Fevers, BR-67030000 Ananindeua, Brazil; 5.NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA; 6.NIAID, Viral Pathogenesis Sect, Viral Dis Lab, NIH, Bethesda, MD 20892 USA; 7.Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 USA; 8.Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA; 9.Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA; 10.Univ Texas Med Branch, Sealy Ctr Vaccine Dev, Galveston, TX 77555 USA; 11.Univ Texas Med Branch, Inst Translat Sci, Galveston, TX 77555 USA; 12.Univ Texas Med Branch, Sealy Ctr Struct Biol & Mol Biophys, Galveston, TX 77555 USA; 13.Para State Univ, Dept Pathol, BR-67087670 Belem, Para, Brazil; 14.Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA; 15.Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA; 16.Washington Univ, Sch Med, Andrew M & Jane M Bursky Ctr Human Immunol & Immu, St Louis, MO 63110 USA; 17.Univ Texas Med Branch, Dept Phamarcol & Toxicol, Galveston, TX 77555 USA |
推荐引用方式 GB/T 7714 | Shan, Chao,Muruato, Antonio E.,Jagger, Brett W.,et al. A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Shan, Chao.,Muruato, Antonio E..,Jagger, Brett W..,Richner, Justin.,Nunes, Bruno T. D..,...&Shi, Pei-Yong.(2019).A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage.NATURE COMMUNICATIONS,8. |
MLA | Shan, Chao,et al."A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage".NATURE COMMUNICATIONS 8(2019). |
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