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DOI | 10.1038/s41467-019-11861-y |
DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1 | |
Wong, Jing Ting1; Akhbar, Farzanah2; Ng, Amanda Yunn Ee3; Tay, Mandy Li-Ian3; Loi, Gladys Jing En4; Pek, Jun Wei3 | |
2019-09-02 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Singapore |
英文摘要 | Stable intronic sequence RNAs (sisRNAs) are by-products of splicing and regulate gene expression. How sisRNAs are regulated is unclear. Here we report that a double-stranded RNA binding protein, Disco-interacting protein 1 (DIP1) regulates sisRNAs in Drosophila. DIP1 negatively regulates the abundance of sisR-1 and INE-1 sisRNAs. Fine-tuning of sisR-1 by DIP1 is important to maintain female germline stem cell homeostasis by modulating germline stem cell differentiation and niche adhesion. Drosophila DIP1 localizes to a nuclear body (satellite body) and associates with the fourth chromosome, which contains a very high density of INE-1 transposable element sequences that are processed into sisRNAs. DIP1 presumably acts outside the satellite bodies to regulate sisR-1, which is not on the fourth chromosome. Thus, our study identifies DIP1 as a sisRNA regulatory protein that controls germline stem cell self-renewal in Drosophila. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000412053100005 |
WOS关键词 | MESSENGER-RNA DEADENYLATION ; INTRONIC SEQUENCE RNAS ; LONG NONCODING RNAS ; DOUBLE-STRANDED-RNA ; SELF-RENEWAL ; CAJAL-BODY ; XENOPUS-TROPICALIS ; CCR4-NOT COMPLEX ; NICHE OCCUPANCY ; DISTINCT ROLES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204518 |
专题 | 资源环境科学 |
作者单位 | 1.Ngee Ann Polytech, 535 Clementi Rd, Singapore 599489, Singapore; 2.Temasek Polytech, 21 Tampines Ave 1, Singapore 529757, Singapore; 3.1 Res Link Natl Univ Singapore, Temasek Life Sci Lab, Singapore 117604, Singapore; 4.Natl Univ Singapore, 21 Lower Kent Ridge Rd, Singapore 119077, Singapore |
推荐引用方式 GB/T 7714 | Wong, Jing Ting,Akhbar, Farzanah,Ng, Amanda Yunn Ee,et al. DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Wong, Jing Ting,Akhbar, Farzanah,Ng, Amanda Yunn Ee,Tay, Mandy Li-Ian,Loi, Gladys Jing En,&Pek, Jun Wei.(2019).DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1.NATURE COMMUNICATIONS,8. |
MLA | Wong, Jing Ting,et al."DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1".NATURE COMMUNICATIONS 8(2019). |
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