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DOI | 10.1038/s41467-019-12322-2 |
Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis | |
Romac, Joelle M. -J.1,2; Shahid, Rafiq A.1,2; Swain, Sandip M.1,2; Vigna, Steven R.1,2,3; Liddle, Rodger A.1,2 | |
2019-09-25 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Merely touching the pancreas can lead to premature zymogen activation and pancreatitis but the mechanism is not completely understood. Here we demonstrate that pancreatic acinar cells express the mechanoreceptor Piezo1 and application of pressure within the gland produces pancreatitis. To determine if this effect is through Piezo1 activation, we induce pancreatitis by intrapancreatic duct instillation of the Piezo1 agonist Yoda1. Pancreatitis induced by pressure within the gland is prevented by a Piezo1 antagonist. In pancreatic acinar cells, Yoda1 stimulates calcium influx and induces calcium-dependent pancreatic injury. Finally, selective acinar cell-specific genetic deletion of Piezo1 protects mice against pressure-induced pancreatitis. Thus, activation of Piezo1 in pancreatic acinar cells is a mechanism for pancreatitis and may explain why pancreatitis develops following pressure on the gland as in abdominal trauma, pancreatic duct obstruction, pancreatography, or pancreatic surgery. Piezo1 blockade may prevent pancreatitis when manipulation of the gland is anticipated. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000431113000003 |
WOS关键词 | ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY ; ENZYME ACTIVATION ; DUCT OBSTRUCTION ; ACINAR-CELLS ; TOUCH ; CA2+ ; MYELOPEROXIDASE ; CHOLECYSTOKININ ; PATHOGENESIS ; ARCHITECTURE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204561 |
专题 | 资源环境科学 |
作者单位 | 1.Duke Univ, Dept Med, Durham, NC 27710 USA; 2.Durham VA Med Ctr, Durham, NC 27710 USA; 3.Duke Univ, Dept Cell Biol, Durham, NC 27710 USA |
推荐引用方式 GB/T 7714 | Romac, Joelle M. -J.,Shahid, Rafiq A.,Swain, Sandip M.,et al. Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Romac, Joelle M. -J.,Shahid, Rafiq A.,Swain, Sandip M.,Vigna, Steven R.,&Liddle, Rodger A..(2019).Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis.NATURE COMMUNICATIONS,9. |
MLA | Romac, Joelle M. -J.,et al."Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis".NATURE COMMUNICATIONS 9(2019). |
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