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DOI | 10.1038/s41467-019-12146-0 |
Extinct type of human parvovirus B19 persists in tonsillar B cells | |
Pyoria, Lari1; Toppinen, Mari1; Mantyla, Elina2,3; Hedman, Lea1,4; Aaltonen, Leena-Maija5; Vihinen-Ranta, Maija2,3; Ilmarinen, Taru5; Soderlund-Venermo, Maria1; Hedman, Klaus1,4; Perdomo, Maria F.1 | |
2019-09-26 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Finland |
英文摘要 | Parvovirus B19 (B19V) DNA persists lifelong in human tissues, but the cell type harbouring it remains unclear. We here explore B19V DNA distribution in B, T and monocyte cell lineages of recently excised tonsillar tissues from 77 individuals with an age range of 2-69 years. We show that B19V DNA is most frequent and abundant among B cells, and within them we find a B19V genotype that vanished from circulation 440 years ago. Since re-infection or re-activation are unlikely with this virus type, this finding supports the maintenance of pathogen-specific humoral immune responses as a consequence of B-cell long-term survival rather than continuous replenishment of the memory pool. Moreover, we demonstrate the mechanism of B19V internalization to be antibody dependent in two B-cell lines as well as in ex vivo isolated tonsillar B cells. This study provides direct evidence for a cell type accountable for B19V DNA tissue persistence. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000398160400001 |
WOS关键词 | REAL-TIME PCR ; HUMAN ERYTHROVIRUSES ; CELLULAR CORECEPTOR ; GENETIC DIVERSITY ; QUANTITATIVE PCR ; SYNOVIAL TISSUE ; PLASMA-CELLS ; BONE-MARROW ; INFECTION ; DNA |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204562 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Helsinki, Dept Virol, Helsinki 00290, Finland; 2.Univ Jyvaskyla, Dept Biol & Environm Sci, Jyvaskyla 40500, Finland; 3.Univ Jyvaskyla, Nanosci Ctr, Jyvaskyla 40500, Finland; 4.Helsinki Univ Hosp, Helsinki 00290, Finland; 5.Helsinki Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Helsinki 00290, Finland |
推荐引用方式 GB/T 7714 | Pyoria, Lari,Toppinen, Mari,Mantyla, Elina,et al. Extinct type of human parvovirus B19 persists in tonsillar B cells[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Pyoria, Lari.,Toppinen, Mari.,Mantyla, Elina.,Hedman, Lea.,Aaltonen, Leena-Maija.,...&Perdomo, Maria F..(2019).Extinct type of human parvovirus B19 persists in tonsillar B cells.NATURE COMMUNICATIONS,8. |
MLA | Pyoria, Lari,et al."Extinct type of human parvovirus B19 persists in tonsillar B cells".NATURE COMMUNICATIONS 8(2019). |
条目包含的文件 | 条目无相关文件。 |
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