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DOI | 10.1038/s41467-019-12655-y |
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels | |
Jiang, Xia1; 39;Reilly, Paul F.2 | |
2019-10-10 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Sweden; England; France; Canada; Austria; Germany; Australia; Netherlands; Finland; Scotland; Ireland; Norway |
英文摘要 | Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7x10(-9) at rs8018720 in SEC23A, and P = 1.9x10(-14) at rs10745742 in AMDHD1). The overall estimate of heritability of 25-hydroxyvitamin D serum concentrations attributable to GWAS common SNPs is 7.5%, with statistically significant loci explaining 38% of this total. Further investigation identifies signal enrichment in immune and hematopoietic tissues, and clustering with autoimmune diseases in cell-type-specific analysis. Larger studies are required to identify additional common SNPs, and to explore the role of rare or structural variants and gene-gene interactions in the heritability of circulating 25-hydroxyvitamin D levels. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000422650500011 |
WOS关键词 | VITAMIN-D LEVELS ; LENTICULO-SUTURAL DYSPLASIA ; PARTITIONING HERITABILITY ; MULTIPLE-SCLEROSIS ; ADOLESCENT TWINS ; CELL-TYPES ; RISK LOCI ; VARIANTS ; DISEASE ; METAANALYSIS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204586 |
专题 | 资源环境科学 |
作者单位 | 1.Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Dept Epidemiol, 677 Huntington Ave, Boston, MA USA; 2.Karolinska Inst, Inst Environm Med, Unit Cardiovasc Epidemiol, Nobels Vagen 13, S-17177 Stockholm, Sweden; 3.Kings Coll London, Inst Psychiat, Dept Social Genet & Dev Psychiat, De Crespigny Pk, London SE5 8AF, England; 4.Inst Pasteur, Ctr Bioinformat Biostat & Biol Integrat C3BI, F-75724 Paris, France; 5.Hebrew SeniorLife, Inst Aging Res, 1200 Ctr St, Boston, MA 02131 USA; 6.Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02115 USA; 7.Harvard Med Sch, Boston, MA 02115 USA; 8.Broad Inst Harvard & Massachusetts Inst Technol, Boston, MA 02142 USA; 9.Dept Med, 3755 Cote Ste Catherine Rd,Suite H-413, Montreal, PQ H3T 1E2, Canada; 10.Dept Human Genet, 3755 Cote Ste Catherine Rd,Suite H-413, Montreal, PQ H3T 1E2, Canada; 11.Dept Epidemiol, 3755 Cote Ste Catherine Rd,Suite H-413, Montreal, PQ H3T 1E2, Canada; 12.Dept Biostat, 3755 Cote Ste Catherine Rd,Suite H-413, Montreal, PQ H3T 1E2, Canada; 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推荐引用方式 GB/T 7714 | Jiang, Xia,39;Reilly, Paul F.. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Jiang, Xia,&39;Reilly, Paul F..(2019).Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.NATURE COMMUNICATIONS,9. |
MLA | Jiang, Xia,et al."Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels".NATURE COMMUNICATIONS 9(2019). |
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