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DOI10.1289/EHP1612
Plasma Concentrations of Per- and Polyfluoroalkyl Substances at Baseline and Associations with Glycemic Indicators and Diabetes Incidence among High-Risk Adults in the Diabetes Prevention Program Trial
Cardenas, Andres1,2; Gold, Diane R.3,4; Hauser, Russ4; Kleinman, Ken P.5; Hivert, Marie-France1,2,6; Calafat, Antonia M.7; Ye, Xiaoyun7; Webster, Thomas F.8; Horton, Edward S.9; Oken, Emily1,2
2017-10-01
发表期刊ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN0091-6765
EISSN1552-9924
出版年2017
卷号125期号:10
文章类型Article
语种英语
国家USA
英文摘要

BACKGROUND: Several per- and polyfluoroalkyl substances (PFAS) are ubiquitous anthropogenic pollutants almost universally detected in humans. Experimental evidence indicates that PFAS alter glucose metabolism and insulin secretion. However, epidemiological studies have yielded inconsistent results.


OBJECTIVE: We sought to examine associations between plasma PFAS concentrations, glycemic indicators, and diabetes incidence among high-risk adults.


METHODS: Within the Diabetes Prevention Program (DPP), a trial for the prevention of type 2 diabetes among high-risk individuals, we quantified baseline plasma concentrations of nine PFAS among 957 participants randomized to a lifestyle intervention or placebo. We evaluated adjusted associations for plasma PEAS concentrations with diabetes incidence and key glycemic indicators measured at baseline and annually over up to 4.6 y.


RESULTS: Plasma PFAS concentrations were similar to those reported in the U.S. population in 1999-2000. At baseline, in cross-sectional analysis, a doubling in plasma perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) concentrations was associated with higher homeostatic model assessment of insulin resistance (HOMA-IR) [beta(PFOS) = 0.39; 95% confidence interval (CI): 0.13, 0.66; beta(PFOA) = 0.64; 95% CI: 0.34, 0.94], beta-cell function (HOMA-beta) (beta(PFOS) = 9.62; 95% CI: 1.55, 17.70; beta(PFOA) = 15.93; 95% CI: 6.78, 25.08), fasting proinsulin (beta(PFOS) = 1.37 pM; 95% CI: 0.50, 2.25; beta(PFOA) = 1.71 pM; 95% CI: 0.72, 2.71), and glycated hemoglobin (HbA(1c)) (beta(PFOS) = 0.03%; 95% CI: 0.002, 0.07; beta(PFOA) = 0.04%; 95% CI: 0.001, 0.07). There was no strong evidence of associations between plasma PFAS concentrations and diahetes incidence or prospective changes in glycemic indicators during the follow-up period.


CONCLUSIONS: At baseline, several PFAS were cross-sectionally associated with small differences in markers of insulin secretion and function. However, there was limited evidence suggesting that PFAS concentrations are associated with diabetes incidence or changes in glycemic indicators during the follow-up period.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000413793300013
WOS关键词GLOMERULAR-FILTRATION-RATE ; LIFE-STYLE INTERVENTION ; PERFLUOROALKYL SUBSTANCES ; PERFLUOROOCTANOIC ACID ; GLUCOSE-HOMEOSTASIS ; ENDOCRINE DISRUPTORS ; METABOLIC SYNDROME ; INSULIN-SECRETION ; SERUM-LEVELS ; EXPOSURE
WOS类目Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS研究方向Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/22232
专题资源环境科学
作者单位1.Harvard Med Sch, Dept Populat Med, Div Chron Dis Res Lifecourse, Boston, MA 02215 USA;
2.Harvard Pilgrim HealthCare Inst, Boston, MA 02215 USA;
3.Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA;
4.Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA;
5.Univ Massachusetts, Sch Publ Hlth & Human Sci, Dept Biostat, Amherst, MA 01003 USA;
6.Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA;
7.Ctr Dis Control & Prevent, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA USA;
8.Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA;
9.Harvard Med Sch, Joslin Diabet Ctr, Boston, MA USA
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Cardenas, Andres,Gold, Diane R.,Hauser, Russ,et al. Plasma Concentrations of Per- and Polyfluoroalkyl Substances at Baseline and Associations with Glycemic Indicators and Diabetes Incidence among High-Risk Adults in the Diabetes Prevention Program Trial[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(10).
APA Cardenas, Andres.,Gold, Diane R..,Hauser, Russ.,Kleinman, Ken P..,Hivert, Marie-France.,...&Oken, Emily.(2017).Plasma Concentrations of Per- and Polyfluoroalkyl Substances at Baseline and Associations with Glycemic Indicators and Diabetes Incidence among High-Risk Adults in the Diabetes Prevention Program Trial.ENVIRONMENTAL HEALTH PERSPECTIVES,125(10).
MLA Cardenas, Andres,et al."Plasma Concentrations of Per- and Polyfluoroalkyl Substances at Baseline and Associations with Glycemic Indicators and Diabetes Incidence among High-Risk Adults in the Diabetes Prevention Program Trial".ENVIRONMENTAL HEALTH PERSPECTIVES 125.10(2017).
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