GSTDTAP  > 资源环境科学
DOI10.1289/EHP1691
Early-Life Selenium Status and Cognitive Function at 5 and 10 Years of Age in Bangladeshi Children
Skroder, Helena1; Kippler, Maria1; Tofail, Fahmida2; Vahter, Marie1
2017-11-01
发表期刊ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN0091-6765
EISSN1552-9924
出版年2017
卷号125期号:11
文章类型Article
语种英语
国家Sweden; Bangladesh
英文摘要

BACKGROUND: In older adults, selenium status has been positively associated with cognitive function. We recently reported a positive association between maternal selenium status in pregnancy and children's cognitive function at 1.5 y.


OBJECTIVE: We followed up the children to assess if prenatal and childhood selenium status was associated with cognitive abilities at 5 and 10 y.


METHODS: This longitudinal cohort study was nested in Maternal and Infant Nutrition Interventions in Matlab (MINIMat), a population-based, randomized supplementation trial in pregnancy in rural Bangladesh. Selenium in maternal blood [erythrocyte fraction (Ery-Se) at baseline] and in child hair and urine was measured using inductively coupled plasma mass spectrometry. Children's cognition at 5 and 10 y was assessed using the Wechsler Preschool and Primary Scale of Intelligence (TM) and the Wechsler Intelligence Scale for Children (R), respectively. In total, 1,408 children were included.


RESULTS: Multivariable-adjusted linear regression analyses showed that prenatal selenium status was positively associated with children's cognitive function at 5 and 10 y. An increase in maternal Ery-Se from the fifth to the 95th percentile [median: 0.44 mu g/g hemoglobin (Hb)] was associated with an increase in full developmental score of 3.5 [95% confidence interval (CI): 0.1, 7.0], corresponding to 0.16 standard deviation (SD) at 5 y, and 8.1 (95% CI: 3.8, 13), corresponding to 0.24 SD at 10 y. In addition, urine and hair selenium concentrations at 5 and 10 y of age were positively associated with cognitive function at 10 y, although associations were inverse for concentrations >= 98th percentile. Some associations were slightly stronger for girls than for boys.


CONCLUSIONS: Measures of prenatal and childhood (below the 98th percentile) selenium status were associated with higher cognitive function scores at 5 and 10 y of age.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000416837300003
WOS关键词GLUTATHIONE-PEROXIDASE ; PARKINSONS-DISEASE ; HUMAN HEALTH ; EXPOSURE ; SUPPLEMENTATION ; METABOLISM ; COHORT ; BLOOD ; NEUROTOXICITY ; PREGNANCY
WOS类目Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS研究方向Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/22357
专题资源环境科学
作者单位1.Karolinska Inst, Inst Environm Med, Box 210, SE-17177 Stockholm, Sweden;
2.Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh
推荐引用方式
GB/T 7714
Skroder, Helena,Kippler, Maria,Tofail, Fahmida,et al. Early-Life Selenium Status and Cognitive Function at 5 and 10 Years of Age in Bangladeshi Children[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(11).
APA Skroder, Helena,Kippler, Maria,Tofail, Fahmida,&Vahter, Marie.(2017).Early-Life Selenium Status and Cognitive Function at 5 and 10 Years of Age in Bangladeshi Children.ENVIRONMENTAL HEALTH PERSPECTIVES,125(11).
MLA Skroder, Helena,et al."Early-Life Selenium Status and Cognitive Function at 5 and 10 Years of Age in Bangladeshi Children".ENVIRONMENTAL HEALTH PERSPECTIVES 125.11(2017).
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