Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP504 |
Prenatal Residential Proximity to Agricultural Pesticide Use and IQ in 7-Year-Old Children | |
Gunier, Robert B.; Bradman, Asa; Harley, Kim G.; Kogut, Katherine; Eskenazi, Brenda | |
2017-05-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:5 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: Residential proximity to agricultural pesticide use has been associated with neural tube defects and autism, but more subtle outcomes such as cognition have not been studied. OBJECTIVES: We evaluated the relationship between prenatal residential proximity to agricultural use of potentially neurotoxic pesticides and neurodevelopment in 7-year-old children. METHODS: Participants included mothers and children (n = 283) living in the agricultural Salinas Valley of California enrolled in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study. We estimated agricultural pesticide use within 1 km of maternal residences during pregnancy using a geographic information system, residential location, and Californias comprehensive agricultural Pesticide Use Report data. We used regression models to evaluate prenatal residential proximity to agricultural use of five potentially neurotoxic pesticide groups (organophosphates, carbamates, pyrethroids, neonicotinoids, and manganese fungicides) and five individual organophosphates (acephate, chlorpyrifos, diazinon, malathion, and oxydemeton-methyl) and cognition in 7-year-old children. All models included prenatal urinary dialkyl phosphate metabolite concentrations. RESULTS: We observed a decrease of 2.2 points [95% confidence interval (CI): -3.9, -0.5] in Full-Scale IQ and 2.9 points (95% CI: -4.4, -1.3) in Verbal Comprehension for each standard deviation increase in toxicity-weighted use of organophosphate pesticides. In separate models, we observed similar decrements in Full-Scale IQ with each standard deviation increase of use for two organophosphates (acephate and oxydemeton-methyl) and three neurotoxic pesticide groups (pyrethroids, neonicotinoids, and manganese fungicides). CONCLUSIONS: This study identified potential relationships between maternal residential proximity to agricultural use of neurotoxic pesticides and poorer neurodevelopment in children. https://doi.org/10.1289/EHP504. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413786500003 |
WOS关键词 | URINARY METABOLITE LEVELS ; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; MEXICAN-AMERICAN CHILDREN ; AUTISM SPECTRUM DISORDERS ; NEURAL-TUBE DEFECTS ; SAN-JOAQUIN VALLEY ; CHAMACOS COHORT ; CARBAMATE PESTICIDES ; PRESCHOOL-CHILDREN ; PREGNANT-WOMEN |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22391 |
专题 | 资源环境科学 |
作者单位 | Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA |
推荐引用方式 GB/T 7714 | Gunier, Robert B.,Bradman, Asa,Harley, Kim G.,et al. Prenatal Residential Proximity to Agricultural Pesticide Use and IQ in 7-Year-Old Children[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(5). |
APA | Gunier, Robert B.,Bradman, Asa,Harley, Kim G.,Kogut, Katherine,&Eskenazi, Brenda.(2017).Prenatal Residential Proximity to Agricultural Pesticide Use and IQ in 7-Year-Old Children.ENVIRONMENTAL HEALTH PERSPECTIVES,125(5). |
MLA | Gunier, Robert B.,et al."Prenatal Residential Proximity to Agricultural Pesticide Use and IQ in 7-Year-Old Children".ENVIRONMENTAL HEALTH PERSPECTIVES 125.5(2017). |
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