Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens

doi:10.1126/science.aay6485

GSTDTAP

DOI	10.1126/science.aay6485
	Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens
	Mina, Michael J.1,2,3,13,14; Kula, Tomasz 1,2; Leng, Yumei 1; Li, Mamie 2; de Vries, Rory D.4; Knip, Mikael 5,6,7; Siljander, Heli 5,6,7; Rewers, Marian 8; Choy, David F.9; Wilson, Mark S.9; Larman, H. Benjamin 10; Nelson, Ashley N.11,15; Griffin, Diane E.11; de Swart, Rik L.4; Elledge, Stephen J.1,2,12
	2019-11-01
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2019
卷号	366 期号:6465 页码:599-+
文章类型	Article
语种	英语
国家	USA; Netherlands; Finland
英文摘要	Measles virus is directly responsible for more than 100,000 deaths yearly. Epidemiological studies have associated measles with increased morbidity and mortality for years after infection, but the reasons why are poorly understood. Measles virus infects immune cells, causing acute immune suppression. To identify and quantify long-term effects of measles on the immune system, we used VirScan, an assay that tracks antibodies to thousands of pathogen epitopes in blood. We studied 77 unvaccinated children before and 2 months after natural measles virus infection. Measles caused elimination of 11 to 73% of the antibody repertoire across individuals. Recovery of antibodies was detected after natural reexposure to pathogens. Notably, these immune system effects were not observed in infants vaccinated against MMR (measles, mumps, and rubella), but were confirmed in measles-infected macaques. The reduction in humoral immune memory after measles infection generates potential vulnerability to future infections, underscoring the need for widespread vaccination.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000494465700042
WOS关键词	HUMORAL IMMUNITY ; DENDRITIC CELLS ; CHILDREN ; AUTOIMMUNITY ; LYMPHOCYTES ; DURATION ; RECEPTOR
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/226127
专题	环境与发展全球科技态势
作者单位	1.Brigham & Womens Hosp, Howard Hughes Med Inst, Div Genet, Boston, MA 02115 USA; 2.Harvard Med Sch, Dept Genet, Boston, MA 02115 USA; 3.Harvard Med Sch, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA; 4.Univ Med Ctr Rotterdam, Erasmus MC, Postgrad Sch Mol Med, Dept Virosci, NL-3015 CN Rotterdam, Netherlands; 5.Univ Helsinki, Childrens Hosp, FIN-00290 Helsinki, Finland; 6.Helsinki Univ Hosp, Helsinki 00290, Finland; 7.Univ Helsinki, Res Program Clin & Mol Metab, FIN-00014 Helsinki, Finland; 8.Univ Colorado, Sch Med, Barbara Davis Ctr Diabet, Denver, CO 80045 USA; 9.Genentech Inc, San Francisco, CA 94080 USA; 10.Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21287 USA; 11.Johns Hopkins Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA; 12.Harvard Med Sch, Program Virol, Boston, MA 02115 USA; 13.Harvard Sch Publ Hlth, Ctr Communicable Dis Dynam, Dept Epidemiol, Boston, MA 02115 USA; 14.Harvard Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA; 15.Duke Univ, Med Ctr, Human Vaccine Inst, Durham, NC 27710 USA
推荐引用方式 GB/T 7714	Mina, Michael J.,Kula, Tomasz,Leng, Yumei,et al. Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens[J]. SCIENCE,2019,366(6465):599-+.
APA	Mina, Michael J..,Kula, Tomasz.,Leng, Yumei.,Li, Mamie.,de Vries, Rory D..,...&Elledge, Stephen J..(2019).Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens.SCIENCE,366(6465),599-+.
MLA	Mina, Michael J.,et al."Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens".SCIENCE 366.6465(2019):599-+.