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DOI | 10.1126/science.aax3769 |
Cellular quality control by the ubiquitin-proteasome system and autophagy | |
Pohl, Christian1,2; Dikic, Ivan1,2,3 | |
2019-11-15 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6467页码:818-+ |
文章类型 | Review |
语种 | 英语 |
国家 | Germany |
英文摘要 | To achieve homeostasis, cells evolved dynamic and self-regulating quality control processes to adapt to new environmental conditions and to prevent prolonged damage. We discuss the importance of two major quality control systems responsible for degradation of proteins and organelles in eukaryotic cells: the ubiquitin-proteasome system (UPS) and autophagy. The UPS and autophagy form an interconnected quality control network where decision-making is self-organized on the basis of biophysical parameters (binding affinities, local concentrations, and avidity) and compartmentalization (through membranes, liquid-liquid phase separation, or the formation of aggregates). We highlight cellular quality control factors that delineate their differential deployment toward macromolecular complexes, liquid-liquid phase-separated subcellular structures, or membrane-bound organelles. Finally, we emphasize the need for continuous promotion of quantitative and mechanistic research into the roles of the UPS and autophagy in human pathophysiology. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000496946200042 |
WOS关键词 | PHASE-SEPARATION ; 26S PROTEASOME ; PATHWAY ; RECEPTOR ; UBIQUITYLATION ; PROTEINS ; DRIVES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/226226 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.Goethe Univ, Fac Med, Inst Biochem 2, D-60590 Frankfurt, Germany; 2.Goethe Univ, Buchmann Inst Mol Life Sci, D-60438 Frankfurt, Germany; 3.Max Planck Inst Biophys, D-60438 Frankfurt, Germany |
推荐引用方式 GB/T 7714 | Pohl, Christian,Dikic, Ivan. Cellular quality control by the ubiquitin-proteasome system and autophagy[J]. SCIENCE,2019,366(6467):818-+. |
APA | Pohl, Christian,&Dikic, Ivan.(2019).Cellular quality control by the ubiquitin-proteasome system and autophagy.SCIENCE,366(6467),818-+. |
MLA | Pohl, Christian,et al."Cellular quality control by the ubiquitin-proteasome system and autophagy".SCIENCE 366.6467(2019):818-+. |
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