Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aax2957 |
Cellular RNA surveillance in health and disease | |
Wolin, Sandra L.1; Maquat, Lynne E.2,3 | |
2019-11-15 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6467页码:822-826 |
文章类型 | Review |
语种 | 英语 |
国家 | USA |
英文摘要 | The numerous quality control pathways that target defective ribonucleic acids (RNAs) for degradation play key roles in shaping mammalian transcriptomes and preventing disease. These pathways monitor most steps in the biogenesis of both noncoding RNAs (ncRNAs) and protein-coding messenger RNAs (mRNAs), degrading ncRNAs that fail to form functional complexes with one or more proteins and eliminating mRNAs that encode abnormal, potentially toxic proteins. Mutations in components of diverse RNA surveillance pathways manifest as disease. Some mutations are characterized by increased interferon production, suggesting that a major role of these pathways is to prevent aberrant cellular RNAs from being recognized as "non-self." Other mutations are common in cancer, or result in developmental defects, revealing the importance of RNA surveillance to cell and organismal function. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000496946200043 |
WOS关键词 | EXOSOME ; DECAY ; MUTATIONS ; TRIGGERS ; PATHWAY ; COMPLEX ; SITES ; ADAR1 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/226227 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.NCI, Ctr Canc Res, RNA Biol Lab, Frederick, MD 21702 USA; 2.Univ Rochester, Sch Med & Dent, Dept Biochem & Biophys, Rochester, NY 14642 USA; 3.Univ Rochester, Ctr RNA Biol, Rochester, NY 14642 USA |
推荐引用方式 GB/T 7714 | Wolin, Sandra L.,Maquat, Lynne E.. Cellular RNA surveillance in health and disease[J]. SCIENCE,2019,366(6467):822-826. |
APA | Wolin, Sandra L.,&Maquat, Lynne E..(2019).Cellular RNA surveillance in health and disease.SCIENCE,366(6467),822-826. |
MLA | Wolin, Sandra L.,et al."Cellular RNA surveillance in health and disease".SCIENCE 366.6467(2019):822-826. |
条目包含的文件 | 条目无相关文件。 |
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