Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aay8746 |
Median raphe controls acquisition of negative experience in the mouse | |
Szonyi, Andras1,4,5; Zicho, Krisztian1; Barth, Albert M.1; Gonczi, Roland T.1; Schlingloff, Daniel1,2; Torok, Bibiana2,3; Sipos, Eszter3; Major, Abel1; Bardoczi, Zsuzsanna1; Sos, Katalin E.1,2; Gulyas, Attila I.1; Varga, Viktor1; Zelena, Dora3; Freund, Tamas F.1; Nyiri, Gabor1 | |
2019-11-29 | |
发表期刊 | SCIENCE
![]() |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6469页码:1094-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Hungary; Switzerland |
英文摘要 | Adverse events need to be quickly evaluated and memorized, yet how these processes are coordinated is poorly understood. We discovered a large population of excitatory neurons in mouse median raphe region (MRR) expressing vesicular glutamate transporter 2 (vGluT2) that received inputs from several negative experience-related brain centers, projected to the main aversion centers, and activated the septohippocampal system pivotal for learning of adverse events. These neurons were selectively activated by aversive but not rewarding stimuli. Their stimulation induced place aversion, aggression, depression-related anhedonia, and suppression of reward-seeking behavior and memory acquisition-promoting hippocampal theta oscillations. By contrast, their suppression impaired both contextual and cued fear memory formation. These results suggest that MRR vGluT2 neurons are crucial for the acquisition of negative experiences and may play a central role in depression-related mood disorders. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000500039200034 |
WOS关键词 | UNBIASED STEREOLOGICAL ESTIMATION ; ROSTROMEDIAL TEGMENTAL NUCLEUS ; LATERAL HABENULA ; HIPPOCAMPAL THETA ; GABAERGIC NEURONS ; LEARNED HELPLESSNESS ; REWARD SIGNALS ; PROJECTIONS ; SYMPTOMS ; MEMORY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/226313 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.Hungarian Acad Sci, Inst Expt Med, Dept Cellular & Network Neurobiol, Lab Cerebral Cortex Res, Budapest, Hungary; 2.Semmelweis Univ, Janos Szentagothai Doctoral Sch Neurosci, Budapest, Hungary; 3.Hungarian Acad Sci, Inst Expt Med, Dept Behav Neurobiol, Lab Behav & Stress Studies, Budapest, Hungary; 4.Friedrich Miescher Inst Biomed Res, Lab Cellular Mech Learning & Memory, Basel, Switzerland; 5.Hungarian Acad Sci, Inst Expt Med, Dept Cellular & Network Neurobiol, Lab Cellular Neurophysiol, Budapest, Hungary |
推荐引用方式 GB/T 7714 | Szonyi, Andras,Zicho, Krisztian,Barth, Albert M.,et al. Median raphe controls acquisition of negative experience in the mouse[J]. SCIENCE,2019,366(6469):1094-+. |
APA | Szonyi, Andras.,Zicho, Krisztian.,Barth, Albert M..,Gonczi, Roland T..,Schlingloff, Daniel.,...&Nyiri, Gabor.(2019).Median raphe controls acquisition of negative experience in the mouse.SCIENCE,366(6469),1094-+. |
MLA | Szonyi, Andras,et al."Median raphe controls acquisition of negative experience in the mouse".SCIENCE 366.6469(2019):1094-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论