Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP875 |
First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls | |
Barrett, Emily S.1,2; Sathyanarayana, Sheela3,4; Mbowe, Omar5; Thurston, Sally W.5; Redmon, J. Bruce6; Nguyen, Ruby H. N.7; Swan, Shanna H.8 | |
2017-07-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:7 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | INTRODUCTION: Evidence from animal models suggests that prenatal exposure to bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical, is associated with adverse reproductive outcomes in females. Exposure during early gestation, a critical period for reproductive development, is of particular concern. Anogenital distance (AGD) is a sensitive biomarker of the fetal hormonal milieu and a measure of reproductive toxicity in animal models. In some studies, the daughters of BPA-exposed dams have shorter AGD than controls. Here, we investigate this relationship in humans. METHODS: BPA was assayed in first-trimester urine samples from 385 participants who delivered infant girls in a multicenter pregnancy cohort study. After birth, daughters underwent exams that included two measures of AGD (AGD-AC: distance from center of anus to clitoris; AGD-AF: distance from center of anus to fourchette). We fit linear regression models to examine the association between specific gravity adjusted (SPG-adj) maternal BPA concentrations and infant AGD, adjusting for covariates. RESULTS: BPA was detectable in 94% of women. In covariate-adjusted models fit on 381 eligible subjects, the natural logarithm of SpG-adj maternal BPA concentration was inversely associated with infant AGD-AC [beta = -0.56, 95% confidence interval (CO: -0.97, 0.15]. We observed no association between maternal BPA and infant AGD-AF. CONCLUSION: BPA may have toxic effects on the female reproductive system in humans, as it does in animal models. Higher first-trimester BPA exposure was associated with significantly shorter AGD in daughters, suggesting that BPA may alter the hormonal environment of the female fetus. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413791300016 |
WOS关键词 | SPRAGUE-DAWLEY RATS ; IN-UTERO EXPOSURE ; ETHINYL ESTRADIOL ; ENVIRONMENTAL CHEMICALS ; SEXUAL-DIFFERENTIATION ; PHTHALATE EXPOSURE ; PRENATAL EXPOSURE ; PREGNANT-WOMEN ; BPA ; GENISTEIN |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22947 |
专题 | 资源环境科学 |
作者单位 | 1.Rutgers State Univ, Environm & Occupat Hlth Sci Inst, Dept Epidemiol, Sch Publ Hlth, 170 Frelinghuysen Rd, Piscataway, NJ 08854 USA; 2.Univ Rochester, Sch Med & Dent, Dept Obstet & Gynecol, Rochester, NY 14642 USA; 3.Univ Washington, Dept Pediat, Seattle, WA 98195 USA; 4.Seattle Childrens Res Inst, Seattle, WA USA; 5.Univ Rochester, Sch Med & Dent, Dept Biostat & Computat Biol, Rochester, NY USA; 6.Univ Minnesota, Dept Med, Box 736 UMHC, Minneapolis, MN 55455 USA; 7.Univ Minnesota, Dept Epidemiol & Community Hlth, Minneapolis, MN USA; 8.Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA |
推荐引用方式 GB/T 7714 | Barrett, Emily S.,Sathyanarayana, Sheela,Mbowe, Omar,et al. First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(7). |
APA | Barrett, Emily S..,Sathyanarayana, Sheela.,Mbowe, Omar.,Thurston, Sally W..,Redmon, J. Bruce.,...&Swan, Shanna H..(2017).First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls.ENVIRONMENTAL HEALTH PERSPECTIVES,125(7). |
MLA | Barrett, Emily S.,et al."First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls".ENVIRONMENTAL HEALTH PERSPECTIVES 125.7(2017). |
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